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10.1016/j.virol.2020.03.007 http://scihub22266oqcxt.onion/10.1016/j.virol.2020.03.007 32452417!7157939!32452417     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2020 ; 546 (ä): 51-66 Nephropedia Template TP {{tp|p=32452417|t=2020. New insights into the evolutionary features of viral overlapping genes by discriminant analysis |pdf=|usr=}}{{32452417}} gab.com Text New insights into the evolutionary features of viral overlapping genes by discriminant analysis JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=32452417 #FOAvip Overlapping genes originate by a mechanism of overprinting, in which nucleotide substitutions in a pre-existing frame induce the expression of a de novo protein from an alternative frame. In this study, I assembled a dataset of 319 viral overlapping genes, which included 82 overlaps whose expression is experimentally known and the respective 237 homologs. Principal component analysis revealed that overlapping genes have a common pattern of nucleotide and amino acid composition. Discriminant analysis separated overlapping from non-overlapping genes with an accuracy of 97%. When applied to overlapping genes with known genealogy, it separated ancestral from de novo frames with an accuracy close to 100%. This high discriminant power was crucial to computationally design variants of de novo viral proteins known to possess selective anticancer toxicity (apoptin) or protection against neurodegeneration (X protein), as well as to detect two new potential overlapping genes in the genome of the new coronavirus SARS-CoV-2. Twit Text FOAVip New insights into the evolutionary features of viral overlapping genes by discriminant analysis ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=32452417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32452417 #FOAvip English Wikipedia <ref>{{Cite pmid|32452417}}</ref> New insights into the evolutionary features of viral overlapping genes by discriminant analysis #MMPMID32452417 Pavesi A Virology 2020[Jul]; 546 (ä): 51-66 PMID32452417show ga Overlapping genes originate by a mechanism of overprinting, in which nucleotide substitutions in a pre-existing frame induce the expression of a de novo protein from an alternative frame. In this study, I assembled a dataset of 319 viral overlapping genes, which included 82 overlaps whose expression is experimentally known and the respective 237 homologs. Principal component analysis revealed that overlapping genes have a common pattern of nucleotide and amino acid composition. Discriminant analysis separated overlapping from non-overlapping genes with an accuracy of 97%. When applied to overlapping genes with known genealogy, it separated ancestral from de novo frames with an accuracy close to 100%. This high discriminant power was crucial to computationally design variants of de novo viral proteins known to possess selective anticancer toxicity (apoptin) or protection against neurodegeneration (X protein), as well as to detect two new potential overlapping genes in the genome of the new coronavirus SARS-CoV-2. |*Evolution, Molecular[MESH] |*Genes, Overlapping[MESH] |*Genes, Viral[MESH] |Algorithms[MESH] |Amino Acid Sequence[MESH] |Base Sequence[MESH] |Betacoronavirus/*genetics[MESH] |Computational Biology[MESH] |Computer Simulation[MESH] |Discriminant Analysis[MESH] |Least-Squares Analysis[MESH] |Principal Component Analysis[MESH]New insights into the evolutionary features of viral overlapping genes(epmc).pdf DeepDyve Pubget Overpricing