Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


suck pdf from google scholar
unlimited free pdf from europmc32452417    free
PDF from PMC    free
html from PMC    free
PDF vom PMID32452417  :  Publisher
PDF vom PMID32452417 :   free
PDF vom PMID32452417

suck abstract from ncbi

Nephropedia Template TP Text

Twit Text FOAVip

Twit Text #

English Wikipedia

  • New insights into the evolutionary features of viral overlapping genes by discriminant analysis #MMPMID32452417
  • Pavesi A
  • Virology 2020[Jul]; 546 (ä): 51-66 PMID32452417show ga
  • Overlapping genes originate by a mechanism of overprinting, in which nucleotide substitutions in a pre-existing frame induce the expression of a de novo protein from an alternative frame. In this study, I assembled a dataset of 319 viral overlapping genes, which included 82 overlaps whose expression is experimentally known and the respective 237 homologs. Principal component analysis revealed that overlapping genes have a common pattern of nucleotide and amino acid composition. Discriminant analysis separated overlapping from non-overlapping genes with an accuracy of 97%. When applied to overlapping genes with known genealogy, it separated ancestral from de novo frames with an accuracy close to 100%. This high discriminant power was crucial to computationally design variants of de novo viral proteins known to possess selective anticancer toxicity (apoptin) or protection against neurodegeneration (X protein), as well as to detect two new potential overlapping genes in the genome of the new coronavirus SARS-CoV-2.
  • |*Evolution, Molecular[MESH]
  • |*Genes, Overlapping[MESH]
  • |*Genes, Viral[MESH]
  • |Algorithms[MESH]
  • |Amino Acid Sequence[MESH]
  • |Base Sequence[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |Computational Biology[MESH]
  • |Computer Simulation[MESH]
  • |Discriminant Analysis[MESH]
  • |Least-Squares Analysis[MESH]
  • |Principal Component Analysis[MESH]
  • |SARS-CoV-2[MESH]

  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    51 ä.546 2020