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10.1007/s40265-020-01321-z http://scihub22266oqcxt.onion/10.1007/s40265-020-01321-z 32451923!7246970!32451923     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32451923.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drugs 2020 ; 80 (10): 941-946 Nephropedia Template TP {{tp|p=32451923|t=2020. The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19 |pdf=|usr=}}{{32451923}} gab.com Text The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19 JO: Drugs http://www.kidney.de/pget.php?&tw=1&pmid=32451923 #FOAvip G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic. Twit Text FOAVip The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19 ????Drugs http://www.kidney.de/pget.php?&tw=1&pmid=32451923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32451923 #FOAvip English Wikipedia <ref>{{Cite pmid|32451923}}</ref> The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19 #MMPMID32451923 Panera N; Tozzi AE; Alisi A Drugs 2020[Jul]; 80 (10): 941-946 PMID32451923show ga G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic. |*G-Quadruplexes[MESH] |Antiviral Agents/*therapeutic use[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy[MESH] |Coronavirus Papain-Like Proteases[MESH] |Drug Repositioning[MESH] |Genome, Viral/*genetics[MESH] |Humans[MESH] |Methyltransferases/antagonists & inhibitors[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |RNA Helicases/*antagonists & inhibitors[MESH] |SARS-CoV-2[MESH]The G-Quadruplex/Helicase World as a Potential Antiviral Approach Agai(epmc).pdf DeepDyve Pubget Overpricing