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Does SARS-CoV-2 infection cause chronic neurological complications? #MMPMID32451846
Hascup ER; Hascup KN
Geroscience 2020[Aug]; 42 (4): 1083-1087 PMID32451846show ga
The current pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has created an unparalleled health crisis. Besides the acute respiratory infection, CoVs are neuroinvasive causing additional inflammation and neurodegeneration. This is likely also true of SARS-CoV-2 given reports of neurological manifestations in coronavirus disease 2019 (COVID-19) positive patients. Older adults > 65 years of age constitute a high-risk group prone to severe infection and death. Despite the higher mortality rate, a majority of cases are expected to recover and survive from this viral outbreak. But, the long-term consequences of SARS-CoV-2 neuroinfection are unknown. We discuss these potential chronic changes to the central nervous system (CNS) in relation to accelerated brain aging and age-related neurodegenerative disorders.
|*Betacoronavirus[MESH]
|COVID-19[MESH]
|Chronic Disease[MESH]
|Coronavirus Infections/*complications[MESH]
|Humans[MESH]
|Nervous System Diseases/*epidemiology/*virology[MESH]