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10.3346/jkms.2020.35.e195 http://scihub22266oqcxt.onion/10.3346/jkms.2020.35.e195 32449329!7246183!32449329     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Korean+Med+Sci 2020 ; 35 (20): e195 Nephropedia Template TP {{tp|p=32449329|t=2020. Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva |pdf=|usr=}}{{32449329}} gab.com Text Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva JO: J Korean Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32449329 #FOAvip BACKGROUND: Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during the early subclinical period. METHODS: We evaluated the viral dynamics in various body fluid specimens, such as nasopharyngeal swab, oropharyngeal swab, saliva, sputum, and urine specimens, of two patients with COVID-19 from hospital day 1 to 9. Additional samples of the saliva were taken at 1 hour, 2 hours, and 4 hours after using a chlorhexidine mouthwash. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load was determined by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). RESULTS: SARS-CoV-2 was detected from all the five specimens of both patients by rRT-PCR. The viral load was the highest in the nasopharynx (patient 1 = 8.41 log(10) copies/mL; patient 2 = 7.49 log(10) copies/mL), but it was also remarkably high in the saliva (patient 1 = 6.63 log(10) copies/mL; patient 2 = 7.10 log(10) copies/mL). SARS-CoV-2 was detected up to hospital day 6 (illness day 9 for patient 2) from the saliva of both patients. The viral load in the saliva decreased transiently for 2 hours after using the chlorhexidine mouthwash. CONCLUSION: SARS-CoV-2 viral load was consistently high in the saliva; it was relatively higher than that in the oropharynx during the early stage of COVID-19. Chlorhexidine mouthwash was effective in reducing the SARS-CoV-2 viral load in the saliva for a short-term period. Twit Text FOAVip Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva ????J Korean Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32449329 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32449329 #FOAvip English Wikipedia <ref>{{Cite pmid|32449329}}</ref> Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva #MMPMID32449329 Yoon JG; Yoon J; Song JY; Yoon SY; Lim CS; Seong H; Noh JY; Cheong HJ; Kim WJ J Korean Med Sci 2020[May]; 35 (20): e195 PMID32449329show ga BACKGROUND: Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during the early subclinical period. METHODS: We evaluated the viral dynamics in various body fluid specimens, such as nasopharyngeal swab, oropharyngeal swab, saliva, sputum, and urine specimens, of two patients with COVID-19 from hospital day 1 to 9. Additional samples of the saliva were taken at 1 hour, 2 hours, and 4 hours after using a chlorhexidine mouthwash. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load was determined by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). RESULTS: SARS-CoV-2 was detected from all the five specimens of both patients by rRT-PCR. The viral load was the highest in the nasopharynx (patient 1 = 8.41 log(10) copies/mL; patient 2 = 7.49 log(10) copies/mL), but it was also remarkably high in the saliva (patient 1 = 6.63 log(10) copies/mL; patient 2 = 7.10 log(10) copies/mL). SARS-CoV-2 was detected up to hospital day 6 (illness day 9 for patient 2) from the saliva of both patients. The viral load in the saliva decreased transiently for 2 hours after using the chlorhexidine mouthwash. CONCLUSION: SARS-CoV-2 viral load was consistently high in the saliva; it was relatively higher than that in the oropharynx during the early stage of COVID-19. Chlorhexidine mouthwash was effective in reducing the SARS-CoV-2 viral load in the saliva for a short-term period. |*Viral Load[MESH] |Aged[MESH] |Betacoronavirus/*isolation & purification[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |COVID-19 Vaccines[MESH] |Clinical Laboratory Techniques[MESH] |Coronavirus Infections/diagnosis/*virology[MESH] |Female[MESH] |Humans[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*virology[MESH] |SARS-CoV-2[MESH]Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva (epmc).pdf DeepDyve Pubget Overpricing