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10.1007/s12094-020-02381-z

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suck abstract from ncbi


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pmid32449128      Clin+Transl+Oncol 2020 ; 22 (12): 2364-2368
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  • Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid #MMPMID32449128
  • Rogado J; Obispo B; Pangua C; Serrano-Montero G; Martin Marino A; Perez-Perez M; Lopez-Alfonso A; Gullon P; Lara MA
  • Clin Transl Oncol 2020[Dec]; 22 (12): 2364-2368 PMID32449128show ga
  • BACKGROUND: There are no large reported series determining the Covid-19 cancer patient's characteristics. We determine whether differences exist in cumulative incidence and mortality of Covid-19 infection between cancer patients and general population in Madrid. MATERIAL AND METHODS: We reviewed 1069 medical records of all cancer patients admitted at Oncology department between Feb 1 and April 7, 2020. We described Covid-19 cumulative incidence, treatment outcome, mortality, and associated risk factors. RESULTS: We detected 45/1069 Covid-19 diagnoses in cancer patients vs 42,450/6,662,000 in total population (p < 0.00001). Mortality rate: 19/45 cancer patients vs 5586/42,450 (p = 0.0001). Mortality was associated with older median age, adjusted by staging and histology (74 vs 63.5 years old, OR 1.06, p = 0.03). Patients who combined hydroxychloroquine and azithromycin presented 3/18 deaths, regardless of age, staging, histology, cancer treatment and comorbidities (OR 0.02, p = 0.03). CONCLUSION: Cancer patients are vulnerable to Covid-19 with an increase in complications. Combined hydroxychloroquine and azithromycin is presented as a good treatment option.
  • |Aged[MESH]
  • |Azithromycin/therapeutic use[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/diagnosis/drug therapy/*mortality[MESH]
  • |Drug Combinations[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Incidence[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neoplasms/*complications/*epidemiology/pathology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/drug therapy/*mortality[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Spain/epidemiology[MESH]


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