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10.3760/cma.j.issn.0253-2727.2020.008 http://scihub22266oqcxt.onion/10.3760/cma.j.issn.0253-2727.2020.008 32447934!7364914!32447934     free     free     free Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538       Zhonghua+Xue+Ye+Xue+Za+Zhi 2020 ; 41 (4): 302-307 Nephropedia Template TP {{tp|p=32447934|t=2020. Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia |pdf=|usr=}}{{32447934}} gab.com Text Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia JO: Zhonghua Xue Ye Xue Za Zhi http://www.kidney.de/pget.php?&tw=1&pmid=32447934 #FOAvip Objective: To investigate the clinical and coagulation characteristics in patients with critical Coronavirus disease 2019 (COVID-19) and acro-ischemia. Methods: The retrospective study included 7 critical COVID-19 patients with acro-ischemia in an intensive care unit (ICU) in Wuhan, from Feb 4 to Feb 15, 2020. The clinical and laboratory data before and during the ICU stay were analyzed. Results: The median age of 7 patients was 59 years and 4 of them were men. Three patients were associated with underlying comorbidities. Fever, cough, dyspnea and diarrhea were common clinical symptoms. All patients had acro-ischemia presentations including finger/toe cyanosis, skin bulla and dry gangrene. D-dimer, fibrinogen and fibrinogen degradation product (FDP) were significantly elevated in most patients. Prothrombin time was prolonged in 4 patients. D-dimer and FDP levels progressively elevated consistent with COVID-2019 exacerbation. Four patients were diagnosed with disseminated intravascular coagulation (DIC) . Low molecular weight heparin (LMWH) was administrated in 6 patients, which reduced D-dimer and FDP rather than improved clinical symptoms. Five patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: Coagulation parameters should be monitored closely in critical COVID-2019 patients. The timing and protocol of anticoagulation therapy are still under investigation based on more clinical data. Twit Text FOAVip Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia ????Zhonghua Xue Ye Xue Za Zhi http://www.kidney.de/pget.php?&tw=1&pmid=32447934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32447934 #FOAvip English Wikipedia <ref>{{Cite pmid|32447934}}</ref> Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia #MMPMID32447934 Zhang Y; Cao W; Xiao M; Li YJ; Yang Y; Zhao J; Zhou X; Jiang W; Zhao YQ; Zhang SY; Li TS Zhonghua Xue Ye Xue Za Zhi 2020[Apr]; 41 (4): 302-307 PMID32447934show ga Objective: To investigate the clinical and coagulation characteristics in patients with critical Coronavirus disease 2019 (COVID-19) and acro-ischemia. Methods: The retrospective study included 7 critical COVID-19 patients with acro-ischemia in an intensive care unit (ICU) in Wuhan, from Feb 4 to Feb 15, 2020. The clinical and laboratory data before and during the ICU stay were analyzed. Results: The median age of 7 patients was 59 years and 4 of them were men. Three patients were associated with underlying comorbidities. Fever, cough, dyspnea and diarrhea were common clinical symptoms. All patients had acro-ischemia presentations including finger/toe cyanosis, skin bulla and dry gangrene. D-dimer, fibrinogen and fibrinogen degradation product (FDP) were significantly elevated in most patients. Prothrombin time was prolonged in 4 patients. D-dimer and FDP levels progressively elevated consistent with COVID-2019 exacerbation. Four patients were diagnosed with disseminated intravascular coagulation (DIC) . Low molecular weight heparin (LMWH) was administrated in 6 patients, which reduced D-dimer and FDP rather than improved clinical symptoms. Five patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: Coagulation parameters should be monitored closely in critical COVID-2019 patients. The timing and protocol of anticoagulation therapy are still under investigation based on more clinical data. |Anticoagulants/*therapeutic use[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |China[MESH] |Coronavirus Infections/*complications/drug therapy[MESH] |Female[MESH] |Fibrin Fibrinogen Degradation Products/analysis[MESH] |Heparin, Low-Molecular-Weight/*therapeutic use[MESH] |Humans[MESH] |Ischemia/*drug therapy/virology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/drug therapy[MESH] |Retrospective Studies[MESH] Clinical and coagulation characteristics in 7 patients with critical (epmc).pdf DeepDyve Pubget Overpricing