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10.1016/j.jcv.2020.104436

http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104436
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suck abstract from ncbi


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pmid32447256      J+Clin+Virol 2020 ; 128 (ä): 104436
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  • Community-acquired viral respiratory infections amongst hospitalized inpatients during a COVID-19 outbreak in Singapore: co-infection and clinical outcomes #MMPMID32447256
  • Wee LE; Ko KKK; Ho WQ; Kwek GTC; Tan TT; Wijaya L
  • J Clin Virol 2020[Jul]; 128 (ä): 104436 PMID32447256show ga
  • AIMS: During the ongoing COVID-19 outbreak, co-circulation of other common respiratory viruses can potentially result in co-infections; however, reported rates of co-infections for SARS-CoV-2 vary. We sought to evaluate the prevalence and etiology of all community acquired viral respiratory infections requiring hospitalization during an ongoing COVID-19 outbreak, with a focus on co-infection rates and clinical outcomes. METHODS: Over a 10-week period, all admissions to our institution, the largest tertiary hospital in Singapore, were screened for respiratory symptoms, and COVID-19 as well as a panel of common respiratory viral pathogens were systematically tested for. Information was collated on clinical outcomes, including requirement for mechanical ventilation and in hospital mortality. RESULTS: One-fifth (19.3%, 736/3807) of hospitalized inpatients with respiratory symptoms had a PCR-proven viral respiratory infection; of which 58.5% (431/736) tested positive for SARS-CoV-2 and 42.2% (311/736) tested positive for other common respiratory viruses. The rate of co-infection with SARS-CoV-2 was 1.4% (6/431); all patients with co-infection had mild disease and stayed in communal settings. The in-hospital mortality rate and proportion of COVID-19 patients requiring invasive ventilation was low, at around 1% of patients; these rates were lower than patients with other community-acquired respiratory viruses admitted over the same period (p < 0.01). CONCLUSION: Even amidst an ongoing COVID-19 outbreak, common respiratory viruses still accounted for a substantial proportion of hospitalizations. Coinfections with SARS-CoV-2 were rare, with no observed increase in morbidity or mortality.
  • |*Disease Outbreaks[MESH]
  • |Adult[MESH]
  • |Betacoronavirus/genetics/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coinfection/*epidemiology/mortality/virology[MESH]
  • |Community-Acquired Infections/*epidemiology/mortality/virology[MESH]
  • |Coronavirus Infections/*epidemiology/mortality/virology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Inpatients[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology/mortality/virology[MESH]
  • |Respiratory Tract Infections/*epidemiology/mortality/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Singapore/epidemiology[MESH]
  • |Tertiary Care Centers[MESH]


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