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10.1016/j.micinf.2020.05.013

http://scihub22266oqcxt.onion/10.1016/j.micinf.2020.05.013
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suck abstract from ncbi


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pmid32446902      Microbes+Infect 2020 ; 22 (4-5): 182-187
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  • Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross-protection against COVID-19 #MMPMID32446902
  • Tilocca B; Soggiu A; Sanguinetti M; Babini G; De Maio F; Britti D; Zecconi A; Bonizzi L; Urbani A; Roncada P
  • Microbes Infect 2020[May]; 22 (4-5): 182-187 PMID32446902show ga
  • Envelope protein of coronaviruses is a structural protein existing in both monomeric and homo-pentameric form. It has been related to a multitude of roles including virus infection, replication, dissemination and immune response stimulation. In the present study, we employed an immunoinformatic approach to investigate the major immunogenic domains of the SARS-CoV-2 envelope protein and map them among the homologue proteins of coronaviruses with tropism for animal species that are closely inter-related with the human beings population all over the world. Also, when not available, we predicted the envelope protein structural folding and mapped SARS-CoV-2 epitopes. Envelope sequences alignment provides evidence of high sequence homology for some of the investigated virus specimens; while the structural mapping of epitopes resulted in the interesting maintenance of the structural folding and epitope sequence localization also in the envelope proteins scoring a lower alignment score. In line with the One-Health approach, our evidences provide a molecular structural rationale for a potential role of taxonomically related coronaviruses in conferring protection from SARS-CoV-2 infection and identifying potential candidates for the development of diagnostic tools and prophylactic-oriented strategies.
  • |Animals[MESH]
  • |Betacoronavirus/classification/genetics/immunology/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Computational Biology/*methods[MESH]
  • |Coronavirus Envelope Proteins[MESH]
  • |Coronavirus Infections/*immunology/*virology[MESH]
  • |Epitope Mapping[MESH]
  • |Gene Expression Regulation, Viral[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |One Health[MESH]
  • |Pandemics[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/*immunology/*virology[MESH]
  • |Protein Conformation[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Alignment[MESH]
  • |Sequence Analysis, Protein[MESH]


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