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10.1111/ctr.13991

http://scihub22266oqcxt.onion/10.1111/ctr.13991
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32446267!7267091!32446267
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suck abstract from ncbi


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pmid32446267      Clin+Transplant 2020 ; 34 (7): e13991
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  • What solid organ transplant healthcare providers should know about renin-angiotensin-aldosterone system inhibitors and COVID-19 #MMPMID32446267
  • Wong SY; Brubaker AL; Wang AX; Taiwo AA; Melcher ML
  • Clin Transplant 2020[Jul]; 34 (7): e13991 PMID32446267show ga
  • The data on the outcomes of solid organ transplant recipients who have contracted coronavirus disease 2019 (COVID-19) are still emerging. Kidney transplant recipients are commonly prescribed renin-angiotensin-aldosterone system (AAS) inhibitors given the prevalence of hypertension, diabetes, and cardiovascular disease. As the angiotensin-converting enzyme 2 (ACE2) facilitates the entry of coronaviruses into target cells, there have been hypotheses that preexisting use of renin-angiotensin-aldosterone system (RAAS) inhibitors may increase the risk of developing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Given the common use of RAAS inhibitors among solid organ transplant recipients, we sought to review the RAAS cascade, the mechanism of SARS-CoV-2 entry, and pertinent data related to the effect of RAAS inhibitors on ACE2 to guide management of solid organ transplant recipients during the COVID-19 pandemic. At present, there is no clear evidence to support the discontinuation of RAAS inhibitors in solid organ transplant recipients during the COVID-19 pandemic.
  • |*Betacoronavirus[MESH]
  • |*Organ Transplantation[MESH]
  • |Angiotensin Receptor Antagonists/*therapeutic use[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/*therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Diseases/complications/*therapy[MESH]
  • |Coronavirus Infections/*complications/diagnosis/therapy[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/therapy[MESH]
  • |Renin-Angiotensin System/physiology[MESH]


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