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10.1016/j.jcv.2020.104425

http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104425
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32446167!7204737!32446167
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suck abstract from ncbi


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pmid32446167      J+Clin+Virol 2020 ; 128 (ä): 104425
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  • Coronavirus disease 2019 in children: Characteristics, antimicrobial treatment, and outcomes #MMPMID32446167
  • Peng H; Gao P; Xu Q; Liu M; Peng J; Wang Y; Xu H
  • J Clin Virol 2020[Jul]; 128 (ä): 104425 PMID32446167show ga
  • BACKGROUND: At present, coronavirus disease 2019 (COVID-19) has spread in many countries. We conducted this study to help pediatricians understand the conditions of COVID-19 in children. METHODS: We retrospectively summarized the characteristics, treatment and outcomes of pediatric cases in Wuhan Children's Hospital which was the only designated hospital for children with COVID-19 in Hubei Province. A Cox proportional hazards regression analysis was used to evaluate factors associated with clinical outcomes. RESULTS: As of February 29, 75 children had been discharged, of which only one was has severe pneumonia and one was critical cases. Children younger than 2 years were more susceptible to COVID-19. All patients have received interferon-alpha nebulization, and eight cases including the severe and critical cases were co-administrated ribavirin. Five patients with mild pneumonia were given arbidol. Twenty-three patients were given traditional Chinese medicine (TCM). The average length of stay (LOS) and the time of SARS-CoV-2 clearance were 10.57 and 6.39 days, respectively. None of the factors was associated with LOS or time of SARS-CoV-2 clearance. CONCLUSIONS: The severity of COVID-19 in pediatric cases were milder than adults. The efficacy of the antiviral therapy in children with COVID-19 remains to be evaluated.
  • |*Disease Susceptibility[MESH]
  • |Adolescent[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/*physiology[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Female[MESH]
  • |Hospitals, Pediatric[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Interferon-alpha/administration & dosage[MESH]
  • |Length of Stay[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pediatricians[MESH]
  • |Pneumonia, Viral/*drug therapy/virology[MESH]
  • |Proportional Hazards Models[MESH]
  • |Retrospective Studies[MESH]
  • |Ribavirin/administration & dosage[MESH]
  • |SARS-CoV-2[MESH]


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