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10.1016/j.gene.2020.144792 http://scihub22266oqcxt.onion/10.1016/j.gene.2020.144792 32445924!7239005!32445924     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32445924&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2020 ; 752 (ä): 144792 Nephropedia Template TP {{tp|p=32445924|t=2020. Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution |pdf=|usr=}}{{32445924}} gab.com Text Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=32445924 #FOAvip The morbidity of SARS-CoV-2 (COVID-19) is reaching 3 Million landmark causing and a serious public health concern globally and it is enigmatic how several antiviral and antibody treatments were not effective in the different period across the globe. With the drastic increasing number of positive cases around the world WHO raised the importance in the assessment of the risk of spread and understanding genetic modifications that could have occurred in the SARS-CoV-2. Using all available deep sequencing data of complete genome from all over the world (NCBI repository), we identified several hundreds of point mutations or SNPs in SARS-CoV-2 all across the genome. This could be the cause for the constant change and differed virulence with an increase in mortality and morbidity. Among the 12 different countries (one sequence from each country) with complete genome sequencing data, we noted the 47 key point mutations or SNPs located along the entire genome that might have impact in the virulence and response to different antivirals against SARS-CoV-2. In this regard, key viral proteins of spike glycoprotein, Nsp1, RdRp and the ORF8 region got heavily mutated within these 3 months via person-to-person passage. We also discuss what could be the possible cause of this rapid mutation in the SARS-CoV-2. Twit Text FOAVip Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=32445924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32445924 #FOAvip English Wikipedia <ref>{{Cite pmid|32445924}}</ref> Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution #MMPMID32445924 Vankadari N Gene 2020[Aug]; 752 (ä): 144792 PMID32445924show ga The morbidity of SARS-CoV-2 (COVID-19) is reaching 3 Million landmark causing and a serious public health concern globally and it is enigmatic how several antiviral and antibody treatments were not effective in the different period across the globe. With the drastic increasing number of positive cases around the world WHO raised the importance in the assessment of the risk of spread and understanding genetic modifications that could have occurred in the SARS-CoV-2. Using all available deep sequencing data of complete genome from all over the world (NCBI repository), we identified several hundreds of point mutations or SNPs in SARS-CoV-2 all across the genome. This could be the cause for the constant change and differed virulence with an increase in mortality and morbidity. Among the 12 different countries (one sequence from each country) with complete genome sequencing data, we noted the 47 key point mutations or SNPs located along the entire genome that might have impact in the virulence and response to different antivirals against SARS-CoV-2. In this regard, key viral proteins of spike glycoprotein, Nsp1, RdRp and the ORF8 region got heavily mutated within these 3 months via person-to-person passage. We also discuss what could be the possible cause of this rapid mutation in the SARS-CoV-2. |*Point Mutation[MESH] |*Polymorphism, Single Nucleotide[MESH] |Americas/epidemiology[MESH] |Asia/epidemiology[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/virology[MESH] |Drug Resistance, Viral[MESH] |Europe/epidemiology[MESH] |Genome, Viral[MESH] |Humans[MESH] |Pandemics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/epidemiology/virology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH]Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution (epmc).pdf DeepDyve Pubget Overpricing