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10.1093/cid/ciaa632

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32444880!7314181!32444880
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suck abstract from ncbi


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pmid32444880      Clin+Infect+Dis 2020 ; 71 (16): 2167-2173
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  • Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington #MMPMID32444880
  • Buckner FS; McCulloch DJ; Atluri V; Blain M; McGuffin SA; Nalla AK; Huang ML; Greninger AL; Jerome KR; Cohen SA; Neme S; Green ML; Chu HY; Kim HN
  • Clin Infect Dis 2020[Nov]; 71 (16): 2167-2173 PMID32444880show ga
  • BACKGROUND: Washington State served as the initial epicenter of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the United States. An understanding of the risk factors and clinical outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) may provide guidance for management. METHODS: All laboratory-confirmed COVID-19 cases in adults admitted to an academic medical center in Seattle, Washington, between 2 March and 26 March 2020 were included. We evaluated individuals with and without severe disease, defined as admission to the intensive care unit or death. RESULTS: One hundred five COVID-19 patients were hospitalized. Thirty-five percent were admitted from a senior home or skilled nursing facility. The median age was 69 years, and half were women. Three or more comorbidities were present in 55% of patients, with hypertension (59%), obesity (47%), cardiovascular disease (38%), and diabetes (33%) being the most prevalent. Most (63%) had symptoms for >/=5 days prior to admission. Only 39% had fever in the first 24 hours, whereas 41% had hypoxia at admission. Seventy-three percent of patients had lymphopenia. Of 50 samples available for additional testing, no viral coinfections were identified. Severe disease occurred in 49%. Eighteen percent of patients were placed on mechanical ventilation, and the overall mortality rate was 33%. CONCLUSIONS: During the early days of the COVID-19 epidemic in Washington State, the disease had its greatest impact on elderly patients with medical comorbidities. We observed high rates of severe disease and mortality in our hospitalized patients.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*epidemiology/mortality/virology[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Lymphopenia/epidemiology/mortality/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*pathogenicity[MESH]


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