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10.1093/infdis/jiaa281

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa281
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32444876!7313959!32444876
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suck abstract from ncbi


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pmid32444876      J+Infect+Dis 2020 ; 222 (4): 551-555
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  • Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice #MMPMID32444876
  • Bao L; Gao H; Deng W; Lv Q; Yu H; Liu M; Yu P; Liu J; Qu Y; Gong S; Lin K; Qi F; Xu Y; Li F; Xiao C; Xue J; Song Z; Xiang Z; Wang G; Wang S; Liu X; Zhao W; Han Y; Wei Q; Qin C
  • J Infect Dis 2020[Jul]; 222 (4): 551-555 PMID32444876show ga
  • We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed seropositivity 14 days after introduction into the same cage with 3 infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be experimentally infected via aerosol inoculation until continued up to 25 minutes with high viral concentrations.
  • |*Betacoronavirus/genetics/immunology/isolation & purification[MESH]
  • |Aerosols[MESH]
  • |Anal Canal/virology[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |COVID-19[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Infections/*transmission[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood[MESH]
  • |Lung/pathology/virology[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Mice, Transgenic[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/genetics[MESH]
  • |Pharynx/virology[MESH]
  • |Pneumonia, Viral/*transmission[MESH]
  • |RNA, Viral/isolation & purification[MESH]
  • |Respiratory System/virology[MESH]
  • |Risk[MESH]
  • |SARS-CoV-2[MESH]
  • |Specific Pathogen-Free Organisms[MESH]
  • |Time Factors[MESH]
  • |Vero Cells[MESH]
  • |Viral Load[MESH]


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