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Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Infect+Dis 2020 ; 222 (4): 551-555 Nephropedia Template TP
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Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice #MMPMID32444876
Bao L; Gao H; Deng W; Lv Q; Yu H; Liu M; Yu P; Liu J; Qu Y; Gong S; Lin K; Qi F; Xu Y; Li F; Xiao C; Xue J; Song Z; Xiang Z; Wang G; Wang S; Liu X; Zhao W; Han Y; Wei Q; Qin C
J Infect Dis 2020[Jul]; 222 (4): 551-555 PMID32444876show ga
We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed seropositivity 14 days after introduction into the same cage with 3 infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be experimentally infected via aerosol inoculation until continued up to 25 minutes with high viral concentrations.