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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Medicina+(B+Aires) 2020 ; 80 (3): 271-274 Nephropedia Template TP
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Hidroxicloroquina Mensajes desde la cardiologia en tiempos de pandemia por coronavirus #MMPMID32442941
Zaidel EJ; Wyss Quintana FS; Sosa Liprandi A; Mendoza I; Marquez MF; Nunez E; Barbosa M; Baranchuk A
Medicina (B Aires) 2020[]; 80 (3): 271-274 PMID32442941show ga
Due to the coronavirus disease 2019 (COVID-19) pandemic, a wide number of compounds are under scrutiny regarding their antiviral activity, one of them being hydroxychloroquine. Cardiac aspects of the use of chloroquine and hydroxychloroquine are reviewed in this manuscript. A non-systematic review of the medical literature was performed. Information about their safety and efficacy as antimalarials, antivirals, as well as in the long-term treatment of rheumatic diseases was collected. We found an anti-inflammatory effect with reduction of longterm cardiovascular events, a very infrequent heart disease due to a lysosomal effect of the drug, and at the hemodynamic level hypotension, tachycardia, and QT interval prolongation, exacerbated when combined with azithromycin. However, the rate of adverse cardiac events of hydroxychloroquine (and chloroquine) was low.