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10.1111/bph.15140 http://scihub22266oqcxt.onion/10.1111/bph.15140 32442317!7280566!32442317     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2020 ; 177 (21): 4845-4850 Nephropedia Template TP {{tp|p=32442317|t=2020. The case for chronotherapy in Covid-19-induced acute respiratory distress syndrome |pdf=|usr=}}{{32442317}} gab.com Text The case for chronotherapy in Covid-19-induced acute respiratory distress syndrome JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32442317 #FOAvip Coronavirus disease 2019 (COVID-19), the disease resulting from infection by a novel coronavirus, SARS-Cov2, has rapidly spread since November 2019 leading to a global pandemic. SARS-Cov2 has infected over four million people and caused over 290,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of acute respiratory distress syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti-inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS, and thus, chronotherapy may be used to effectively manage ARDS in COVID-19 patients. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. Twit Text FOAVip The case for chronotherapy in Covid-19-induced acute respiratory distress syndrome ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32442317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32442317 #FOAvip English Wikipedia <ref>{{Cite pmid|32442317}}</ref> The case for chronotherapy in Covid-19-induced acute respiratory distress syndrome #MMPMID32442317 Tamimi F; Abusamak M; Akkanti B; Chen Z; Yoo SH; Karmouty-Quintana H Br J Pharmacol 2020[Nov]; 177 (21): 4845-4850 PMID32442317show ga Coronavirus disease 2019 (COVID-19), the disease resulting from infection by a novel coronavirus, SARS-Cov2, has rapidly spread since November 2019 leading to a global pandemic. SARS-Cov2 has infected over four million people and caused over 290,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of acute respiratory distress syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti-inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS, and thus, chronotherapy may be used to effectively manage ARDS in COVID-19 patients. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. |Animals[MESH] |Anti-Inflammatory Agents/administration & dosage/adverse effects[MESH] |Betacoronavirus/immunology/isolation & purification[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Circadian Rhythm/physiology[MESH] |Coronavirus Infections/*drug therapy/immunology/virology[MESH] |Cytokine Release Syndrome/drug therapy/virology[MESH] |Drug Chronotherapy[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/immunology/virology[MESH] |Respiratory Distress Syndrome/*drug therapy/immunology/virology[MESH]The case for chronotherapy in Covid-19-induced acute respiratory distr(epmc).pdf DeepDyve Pubget Overpricing