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10.1002/jcph.1644 http://scihub22266oqcxt.onion/10.1002/jcph.1644 32441805!7280635!32441805     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Pharmacol 2020 ; 60 (7): 815-825 Nephropedia Template TP {{tp|p=32441805|t=2020. Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin |pdf=|usr=}}{{32441805}} gab.com Text Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin JO: J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32441805 #FOAvip Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that induce intra-alveolar fibrin accumulation that reduces the gas exchange. Therefore, an add-on therapy with drugs able to reduce inflammation, edema, and cell activation has been proposed as well as a treatment with interferon, corticosteroids or monoclonal antibodies (eg, tocilizumab). In this article reviewing literature data related to the use of escin, an agent having potent anti-inflammatory and anti-viral effects in lung injury, we suggest that it could represent a therapeutic opportunity as add-on therapy in ALI related to COVID-19 infection. Twit Text FOAVip Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin ????J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32441805 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32441805 #FOAvip English Wikipedia <ref>{{Cite pmid|32441805}}</ref> Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin #MMPMID32441805 Gallelli L; Zhang L; Wang T; Fu F J Clin Pharmacol 2020[Jul]; 60 (7): 815-825 PMID32441805show ga Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that induce intra-alveolar fibrin accumulation that reduces the gas exchange. Therefore, an add-on therapy with drugs able to reduce inflammation, edema, and cell activation has been proposed as well as a treatment with interferon, corticosteroids or monoclonal antibodies (eg, tocilizumab). In this article reviewing literature data related to the use of escin, an agent having potent anti-inflammatory and anti-viral effects in lung injury, we suggest that it could represent a therapeutic opportunity as add-on therapy in ALI related to COVID-19 infection. |Acute Lung Injury/*etiology/physiopathology[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Antiviral Agents/therapeutic use[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/*drug therapy/physiopathology[MESH] |Drug Therapy, Combination[MESH] |Escin/administration & dosage/pharmacology/*therapeutic use[MESH] |Humans[MESH] |Immunologic Factors/therapeutic use[MESH] |Inflammation Mediators/metabolism[MESH] |Lung/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*drug therapy/physiopathology[MESH]Severe Acute Lung Injury Related to COVID-19 Infection: A Review and t(epmc).pdf DeepDyve Pubget Overpricing