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10.1111/bph.15138 http://scihub22266oqcxt.onion/10.1111/bph.15138 32441783!7280564!32441783     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2020 ; 177 (21): 4990-4994 Nephropedia Template TP {{tp|p=32441783|t=2020. A rationale for targeting the P2X7 receptor in Coronavirus disease 19 |pdf=|usr=}}{{32441783}} gab.com Text A rationale for targeting the P2X7 receptor in Coronavirus disease 19 JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32441783 #FOAvip Severe pneumonia which shares several of the features of acute respiratory distress syndrome (ARDS) is the main cause of morbidity and mortality in Coronavirus disease 19 (Covid-19) for which there is no effective treatment, so far. ARDS is caused and sustained by an uncontrolled inflammatory activation characterized by a massive release of cytokines (cytokine storm), diffuse lung oedema, inflammatory cell infiltration, and disseminated coagulation. Macrophage and T lymphocyte dysfunction plays a central role in this syndrome. In several experimental in vitro and in vivo models, many of these pathophysiological changes are triggered by stimulation of the P2X7 receptor. We hypothesize that this receptor might be an ideal candidate to target in Covid-19-associated severe pneumonia. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. Twit Text FOAVip A rationale for targeting the P2X7 receptor in Coronavirus disease 19 ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32441783 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32441783 #FOAvip English Wikipedia <ref>{{Cite pmid|32441783}}</ref> A rationale for targeting the P2X7 receptor in Coronavirus disease 19 #MMPMID32441783 Di Virgilio F; Tang Y; Sarti AC; Rossato M Br J Pharmacol 2020[Nov]; 177 (21): 4990-4994 PMID32441783show ga Severe pneumonia which shares several of the features of acute respiratory distress syndrome (ARDS) is the main cause of morbidity and mortality in Coronavirus disease 19 (Covid-19) for which there is no effective treatment, so far. ARDS is caused and sustained by an uncontrolled inflammatory activation characterized by a massive release of cytokines (cytokine storm), diffuse lung oedema, inflammatory cell infiltration, and disseminated coagulation. Macrophage and T lymphocyte dysfunction plays a central role in this syndrome. In several experimental in vitro and in vivo models, many of these pathophysiological changes are triggered by stimulation of the P2X7 receptor. We hypothesize that this receptor might be an ideal candidate to target in Covid-19-associated severe pneumonia. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. |Animals[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy/physiopathology/virology[MESH] |Cytokine Release Syndrome/virology[MESH] |Humans[MESH] |Macrophages/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/physiopathology/virology[MESH] |Receptors, Purinergic P2X7/*drug effects/metabolism[MESH] |Respiratory Distress Syndrome/*drug therapy/virology[MESH] |SARS-CoV-2[MESH]A rationale for targeting the P2X7 receptor in Coronavirus disease 19 (epmc).pdf DeepDyve Pubget Overpricing