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10.1007/s15010-020-01446-z

http://scihub22266oqcxt.onion/10.1007/s15010-020-01446-z
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32440918!7240242!32440918
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  • A simple algorithm helps early identification of SARS-CoV-2 infection patients with severe progression tendency #MMPMID32440918
  • Li Q; Zhang J; Ling Y; Li W; Zhang X; Lu H; Chen L
  • Infection 2020[Aug]; 48 (4): 577-584 PMID32440918show ga
  • OBJECTIVES: We aimed to develop a simple algorithm to help early identification of SARS-CoV-2 infection patients with severe progression tendency. METHODS: The univariable and multivariable analysis were computed to identify the independent predictors of COVID-19 progression. The prediction model was established in a retrospective training set of 322 COVID-19 patients and was re-evaluated in a prospective validation set of 317 COVID-19 patients. RESULTS: The multivariable analysis identified age (OR = 1.061, p = 0.028), lactate dehydrogenase (LDH) (OR = 1.006, p = 0.037), and CD4 count (OR = 0.993, p = 0.006) as the independent predictors of COVID-19 progression. Consequently, the age-LDH-CD4 algorithm was derived as (age x LDH)/CD4 count. In the training set, the area under the ROC curve (AUROC) of age-LDH-CD4 model was significantly higher than that of single CD4 count, LDH, or age (0.92, 0.85, 0.80, and 0.75, respectively). In the prospective validation set, the AUROC of age-LDH-CD4 model was also significantly higher than that of single CD4 count, LDH, or age (0.92, 0.75, 0.81, and 0.82, respectively). The age-LDH-CD4 >/= 82 has high sensitive (81%) and specific (93%) for the early identification of COVID-19 patients with severe progression tendency. CONCLUSIONS: The age-LDH-CD4 model is a simple algorithm for early identifying patients with severe progression tendency following SARS-CoV-2 infection, and warrants further validation.
  • |*Algorithms[MESH]
  • |*Disease Progression[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Betacoronavirus[MESH]
  • |CD4 Lymphocyte Count[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |L-Lactate Dehydrogenase/analysis[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |Predictive Value of Tests[MESH]
  • |Prospective Studies[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]


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  • suck abstract from ncbi

    577 4.48 2020