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10.3174/ajnr.A6607

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suck abstract from ncbi


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pmid32439651      AJNR+Am+J+Neuroradiol 2020 ; 41 (7): 1165-1169
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  • CT Scanning in Suspected Stroke or Head Trauma: Is it Worth Going the Extra Mile and Including the Chest to Screen for COVID-19 Infection? #MMPMID32439651
  • Kwee RM; Krdzalic J; Fasen BACM; de Jaegere TMH
  • AJNR Am J Neuroradiol 2020[Jul]; 41 (7): 1165-1169 PMID32439651show ga
  • BACKGROUND AND PURPOSE: Chest CT may be used as a tool for rapid coronavirus disease 2019 (COVID-19) detection. Our aim was to investigate the value of additional chest CT for detection of coronavirus 19 (COVID-19) in patients who undergo head CT for suspected stroke or head trauma in a COVID-19-endemic region. MATERIALS AND METHODS: Our study included 27 patients (mean age, 74 years; range, 54-90 years; 20 men) who underwent head CT for suspected stroke (n = 21) or head trauma (n = 6), additional chest CT for COVID-19 detection, and real-time reverse transcriptase polymerase chain reaction testing in a COVID-19-endemic region. Sensitivity, specificity, and negative and positive predictive values of chest CT in detecting COVID-19 were calculated. RESULTS: Final neurologic diagnoses were ischemic stroke (n = 11), brain contusion (n = 5), nontraumatic intracranial hemorrhage (n = 2), brain metastasis (n = 1), and no primary neurologic disorder (n = 8). Symptoms of possible COVID-19 infection (ie, fever, cough, and/or shortness of breath) were present in 20 of 27 (74%) patients. Seven of 27 patients (26%) had real-time reverse transcriptase polymerase chain reaction confirmed-COVID-19 infection. Chest CT results were 6 true-positives, 15 true-negatives, 5 false-positives, and 1 false-negative. Diagnostic performance values of chest CT were a sensitivity of 85.7%, specificity of 75.0%, negative predictive value of 93.8%, and positive predictive value of 54.6%. CONCLUSIONS: The sensitivity of additional chest CT is fairly high. However, a negative result does not exclude COVID-19. The positive predictive value is poor. Correlation of chest CT results with epidemiologic history and clinical presentation, along with real-time reverse transcriptase polymerase chain reaction, is needed for confirmation.
  • |*Betacoronavirus[MESH]
  • |*Coronavirus Infections/complications[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/complications[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19[MESH]
  • |Craniocerebral Trauma/*diagnostic imaging/etiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2[MESH]
  • |Stroke/*diagnostic imaging/etiology[MESH]


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