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10.1016/j.dsx.2020.05.013 http://scihub22266oqcxt.onion/10.1016/j.dsx.2020.05.013 32438331!7205616!32438331     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32438331&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Metab+Syndr 2020 ; 14 (4): 671-677 Nephropedia Template TP {{tp|p=32438331|t=2020. Diabetes and metabolic syndrome as risk factors for COVID-19 |pdf=|usr=}}{{32438331}} gab.com Text Diabetes and metabolic syndrome as risk factors for COVID-19 JO: Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32438331 #FOAvip BACKGROUND AND AIMS: Clinical evidence exists that patients with diabetes are at higher risk for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this clinical observation linking diabetes with severity and adverse outcome of COVID-19. METHODS: Publication mining was applied to reveal common physiological contexts in which diabetes and COVID-19 have been investigated simultaneously. Overall, we have acquired 1,121,078 publications from PubMed in the time span between 01-01-2000 and 17-04-2020, and extracted knowledge graphs interconnecting the topics related to diabetes and COVID-19. RESULTS: The Data Mining revealed three pathophysiological pathways linking diabetes and COVID-19. The first pathway indicates a higher risk for COVID-19 because of a dysregulation of Angiotensin-converting enzyme 2. The other two important physiological links between diabetes and COVID-19 are liver dysfunction and chronic systemic inflammation. A deep network analysis has suggested clinical biomarkers predicting the higher risk: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. CONCLUSIONS: The revealed biomarkers can be applied directly in clinical practice. For newly infected patients, the medical history needs to be checked for evidence of a long-term, chronic dysregulation of these biomarkers. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention. Twit Text FOAVip Diabetes and metabolic syndrome as risk factors for COVID-19 ????Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32438331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32438331 #FOAvip English Wikipedia <ref>{{Cite pmid|32438331}}</ref> Diabetes and metabolic syndrome as risk factors for COVID-19 #MMPMID32438331 Marhl M; Grubelnik V; Magdic M; Markovic R Diabetes Metab Syndr 2020[Jul]; 14 (4): 671-677 PMID32438331show ga BACKGROUND AND AIMS: Clinical evidence exists that patients with diabetes are at higher risk for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this clinical observation linking diabetes with severity and adverse outcome of COVID-19. METHODS: Publication mining was applied to reveal common physiological contexts in which diabetes and COVID-19 have been investigated simultaneously. Overall, we have acquired 1,121,078 publications from PubMed in the time span between 01-01-2000 and 17-04-2020, and extracted knowledge graphs interconnecting the topics related to diabetes and COVID-19. RESULTS: The Data Mining revealed three pathophysiological pathways linking diabetes and COVID-19. The first pathway indicates a higher risk for COVID-19 because of a dysregulation of Angiotensin-converting enzyme 2. The other two important physiological links between diabetes and COVID-19 are liver dysfunction and chronic systemic inflammation. A deep network analysis has suggested clinical biomarkers predicting the higher risk: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. CONCLUSIONS: The revealed biomarkers can be applied directly in clinical practice. For newly infected patients, the medical history needs to be checked for evidence of a long-term, chronic dysregulation of these biomarkers. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention. |Angiotensin-Converting Enzyme 2[MESH] |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/mortality/physiopathology[MESH] |Diabetes Mellitus/*immunology/mortality/physiopathology[MESH] |Humans[MESH] |Metabolic Syndrome/*immunology/mortality/physiopathology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*immunology[MESH] |Pneumonia, Viral/*immunology/mortality/physiopathology[MESH]Diabetes and metabolic syndrome as risk factors for COVID-19 (epmc).pdf DeepDyve Pubget Overpricing