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10.1016/j.mehy.2020.109754

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109754
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32438240!7194918!32438240
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suck abstract from ncbi


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pmid32438240      Med+Hypotheses 2020 ; 142 (ä): 109754
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  • 5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection #MMPMID32438240
  • Ahmad SI
  • Med Hypotheses 2020[Sep]; 142 (ä): 109754 PMID32438240show ga
  • The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will continue and how much more destruction it is going to cause until complete control is achieved. One of the most disturbing issues is Covid-19 treatment; although a large number of medications, previously used successfully with other viruses (including Chinese herbal medicines and anti-malaria drugs), are under consideration, there remain questions as to whether they can play a satisfactory role for this disease. Global attempts are ongoing to find the drugs for the treatment of this virus but none of the antiviral drugs used for treatment of other human viral infection is working and hence attempts to find new drugs are continuing. Here the author is proposing that 5-Fluorouracil (5-FU) which when used on its own is failing as an antiviral agent due to the removal of this compound by proof reading ability exceptionally found in Coronaviruses. The author here is proposing to test 5-FU in combination with a number of deoxynucleosides on animal models infected with this Covid-19. Should encouraging results ensue, therapies could then be tried on patients.
  • |Adenosine Monophosphate/administration & dosage/analogs & derivatives[MESH]
  • |Alanine/administration & dosage/analogs & derivatives[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Chloroquine/administration & dosage/analogs & derivatives[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Deoxyribonucleosides/*administration & dosage[MESH]
  • |Deoxyribose/*administration & dosage[MESH]
  • |Drug Administration Schedule[MESH]
  • |Drug Synergism[MESH]
  • |Fluorouracil/*administration & dosage[MESH]
  • |Humans[MESH]
  • |Inflammation/drug therapy[MESH]
  • |Models, Theoretical[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]


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