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10.1016/j.cell.2020.04.042 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.04.042 32437659!7196902!32437659     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 181 (5): 969-977 Nephropedia Template TP {{tp|p=32437659|t=2020. Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection |pdf=|usr=}}{{32437659}} gab.com Text Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32437659 #FOAvip SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the elderly and individuals with co-morbidities argues for an initial defect in anti-viral host defense mechanisms. Long-term boosting of innate immune responses, also termed "trained immunity," by certain live vaccines (BCG, oral polio vaccine, measles) induces heterologous protection against infections through epigenetic, transcriptional, and functional reprogramming of innate immune cells. We propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2. Twit Text FOAVip Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32437659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32437659 #FOAvip English Wikipedia <ref>{{Cite pmid|32437659}}</ref> Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection #MMPMID32437659 Netea MG; Giamarellos-Bourboulis EJ; Dominguez-Andres J; Curtis N; van Crevel R; van de Veerdonk FL; Bonten M Cell 2020[May]; 181 (5): 969-977 PMID32437659show ga SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the elderly and individuals with co-morbidities argues for an initial defect in anti-viral host defense mechanisms. Long-term boosting of innate immune responses, also termed "trained immunity," by certain live vaccines (BCG, oral polio vaccine, measles) induces heterologous protection against infections through epigenetic, transcriptional, and functional reprogramming of innate immune cells. We propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2. |*Immunity, Innate/drug effects[MESH] |*Immunomodulation[MESH] |Animals[MESH] |BCG Vaccine/immunology[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Clinical Trials as Topic[MESH] |Coronavirus Infections/*immunology/pathology/physiopathology/transmission[MESH] |Humans[MESH] |Lung/immunology/pathology[MESH] |Lymphopenia/pathology[MESH] |Middle East Respiratory Syndrome Coronavirus/physiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/pathology/physiopathology/transmission[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/immunology/pathology[MESH] |Severe acute respiratory syndrome-related coronavirus/*physiology[MESH]Trained Immunity: a Tool for Reducing Susceptibility to and the Severi(epmc).pdf DeepDyve Pubget Overpricing