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10.3201/eid2609.202095

http://scihub22266oqcxt.onion/10.3201/eid2609.202095
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32437316!7454055!32437316
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suck abstract from ncbi


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pmid32437316      Emerg+Infect+Dis 2020 ; 26 (9): 2005-2015
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  • Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States #MMPMID32437316
  • Martines RB; Ritter JM; Matkovic E; Gary J; Bollweg BC; Bullock H; Goldsmith CS; Silva-Flannery L; Seixas JN; Reagan-Steiner S; Uyeki T; Denison A; Bhatnagar J; Shieh WJ; Zaki SR
  • Emerg Infect Dis 2020[Sep]; 26 (9): 2005-2015 PMID32437316show ga
  • An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the histopathology and cellular localization of SARS-CoV-2 in the tissues of patients with fatal COVID-19 is critical to further understand its pathogenesis and transmission and for public health prevention measures. We report clinicopathologic, immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV-2 infection in the United States. All cases except 1 were in residents of long-term care facilities. In these patients, SARS-CoV-2 infected epithelium of the upper and lower airways with diffuse alveolar damage as the predominant pulmonary pathology. SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. Respiratory viral co-infections were identified in 3 cases; 3 cases had evidence of bacterial co-infection.
  • |Aged[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*pathology/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunohistochemistry[MESH]
  • |Lung/pathology/virology[MESH]
  • |Male[MESH]
  • |Microscopy, Electron[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*pathology/virology[MESH]
  • |SARS-CoV-2[MESH]


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