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10.1152/physiolgenomics.00045.2020 http://scihub22266oqcxt.onion/10.1152/physiolgenomics.00045.2020 32437232!7303726!32437232     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Genomics 2020 ; 52 (6): 255-268 Nephropedia Template TP {{tp|p=32437232|t=2020. Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19 |pdf=|usr=}}{{32437232}} gab.com Text Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19 JO: Physiol Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32437232 #FOAvip Precision medicine requires the translation of basic biological understanding to medical insights, mainly applied to characterization of each unique patient. In many clinical settings, this requires tools that can be broadly used to identify pathology and risks. Patients often present to the intensive care unit with broad phenotypes, including multiple organ dysfunction syndrome (MODS) resulting from infection, trauma, or other disease processes. Etiology and outcomes are unique to individuals, making it difficult to cohort patients with MODS, but presenting a prime target for testing/developing tools for precision medicine. Using multitime point whole blood (cellular/acellular) total transcriptomics in 27 patients, we highlight the promise of simultaneously mapping viral/bacterial load, cell composition, tissue damage biomarkers, balance between syndromic biology versus environmental response, and unique biological insights in each patient using a single platform measurement. Integration of a transcriptome workflow yielded unexpected insights into the complex interplay between host genetics and viral/bacterial specific mechanisms, highlighted by a unique case of virally induced genetics (VIG) within one of these 27 patients. The power of RNA-Seq to study unique patient biology while investigating environmental contributions can be a critical tool moving forward for translational sciences applied to precision medicine. Twit Text FOAVip Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19 ????Physiol Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32437232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32437232 #FOAvip English Wikipedia <ref>{{Cite pmid|32437232}}</ref> Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19 #MMPMID32437232 Prokop JW; Shankar R; Gupta R; Leimanis ML; Nedveck D; Uhl K; Chen B; Hartog NL; Van Veen J; Sisco JS; Sirpilla O; Lydic T; Boville B; Hernandez A; Braunreiter C; Kuk CC; Singh V; Mills J; Wegener M; Adams M; Rhodes M; Bachmann AS; Pan W; Byrne-Steele ML; Smith DC; Depinet M; Brown BE; Eisenhower M; Han J; Haw M; Madura C; Sanfilippo DJ; Seaver LH; Bupp C; Rajasekaran S Physiol Genomics 2020[Jun]; 52 (6): 255-268 PMID32437232show ga Precision medicine requires the translation of basic biological understanding to medical insights, mainly applied to characterization of each unique patient. In many clinical settings, this requires tools that can be broadly used to identify pathology and risks. Patients often present to the intensive care unit with broad phenotypes, including multiple organ dysfunction syndrome (MODS) resulting from infection, trauma, or other disease processes. Etiology and outcomes are unique to individuals, making it difficult to cohort patients with MODS, but presenting a prime target for testing/developing tools for precision medicine. Using multitime point whole blood (cellular/acellular) total transcriptomics in 27 patients, we highlight the promise of simultaneously mapping viral/bacterial load, cell composition, tissue damage biomarkers, balance between syndromic biology versus environmental response, and unique biological insights in each patient using a single platform measurement. Integration of a transcriptome workflow yielded unexpected insights into the complex interplay between host genetics and viral/bacterial specific mechanisms, highlighted by a unique case of virally induced genetics (VIG) within one of these 27 patients. The power of RNA-Seq to study unique patient biology while investigating environmental contributions can be a critical tool moving forward for translational sciences applied to precision medicine. |COVID-19[MESH] |Coronavirus Infections/*genetics/*virology[MESH] |Gene Expression Profiling/*methods[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*genetics/*virology[MESH] |Precision Medicine/*methods[MESH] |Transcription, Genetic[MESH]Virus-induced genetics revealed by multidimensional precision medicine(epmc).pdf DeepDyve Pubget Overpricing