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10.1111/jgh.15112

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32436622!7280625!32436622
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suck abstract from ncbi


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pmid32436622      J+Gastroenterol+Hepatol 2021 ; 36 (1): 204-207
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  • Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients #MMPMID32436622
  • Gao F; Zheng KI; Wang XB; Yan HD; Sun QF; Pan KH; Wang TY; Chen YP; George J; Zheng MH
  • J Gastroenterol Hepatol 2021[Jan]; 36 (1): 204-207 PMID32436622show ga
  • BACKGROUND AND AIM: Coronavirus disease 2019 (COVID-19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVID-19 severity, it is not known whether nondiabetic patients with metabolic dysfunction are also more prone to more severe disease. The association of metabolic associated fatty liver disease (MAFLD) with COVID-19 severity in nondiabetic patients was investigated here. METHODS: The study cohort comprised 65 patients with (i.e. cases) and 65 patients without MAFLD (i.e. controls). Each case was randomly matched with one control by sex (1:1) and age (+/-5 years). The association between the presence of MAFLD (as exposure) and COVID-19 severity (as the outcome) was assessed by binary logistic regression analysis. RESULTS: In nondiabetic patients with COVID-19, the presence of MAFLD was associated with a four-fold increased risk of severe COVID-19; the risk increased with increasing numbers of metabolic risk factors. The association with COVID-19 severity persisted after adjusting for age, sex, and coexisting morbid conditions. CONCLUSION: Health-care professionals caring for nondiabetic patients with COVID-19 should be cognizant of the increased likelihood of severe COVID-19 in patients with MAFLD.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/*diagnosis/*epidemiology[MESH]
  • |Case-Control Studies[MESH]
  • |China[MESH]
  • |Cohort Studies[MESH]
  • |Fatty Liver/*complications/diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Risk Factors[MESH]
  • |Severity of Illness Index[MESH]


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