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10.1177/1753466620926800

http://scihub22266oqcxt.onion/10.1177/1753466620926800
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32436460!7243041!32436460
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suck abstract from ncbi


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pmid32436460      Ther+Adv+Respir+Dis 2020 ; 14 (ä): 1753466620926800
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  • TNFalpha inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis #MMPMID32436460
  • Chen XY; Yan BX; Man XY
  • Ther Adv Respir Dis 2020[Jan]; 14 (ä): 1753466620926800 PMID32436460show ga
  • Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFalpha, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section.
  • |Betacoronavirus/immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/*drug therapy[MESH]
  • |Cytokine Release Syndrome/drug therapy/*etiology/physiopathology[MESH]
  • |Etanercept/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/*drug therapy[MESH]
  • |SARS-CoV-2[MESH]
  • |Stevens-Johnson Syndrome/*drug therapy[MESH]
  • |Tumor Necrosis Factor Inhibitors/*therapeutic use[MESH]


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