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10.1016/j.it.2020.04.009 http://scihub22266oqcxt.onion/10.1016/j.it.2020.04.009 32434680!7183997!32434680     free     free     free       Trends+Immunol 2020 ; 41 (7): 586-600 Nephropedia Template TP {{tp|p=32434680|t=2020. AID in Antibody Diversification: There and Back Again |pdf=|usr=}}{{32434680}} gab.com Text AID in Antibody Diversification: There and Back Again JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32434680 #FOAvip Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we review the current understanding of AID function. We discuss AID biochemistry and how error-free forms of DNA repair are co-opted to prioritize mutagenesis over accuracy during antibody diversification. We discuss the regulation of DNA double-strand break (DSB) repair pathways during CSR. We describe genomic targeting of AID as a multilayered process involving chromatin architecture, cis- and trans-acting factors, and determining mutagenesis - distinct from AID occupancy at loci that are spared from mutation. Twit Text FOAVip AID in Antibody Diversification: There and Back Again ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32434680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32434680 #FOAvip English Wikipedia <ref>{{Cite pmid|32434680}}</ref> AID in Antibody Diversification: There and Back Again #MMPMID32434680 Feng Y; Seija N; Di Noia JM; Martin A Trends Immunol 2020[Jul]; 41 (7): 586-600 PMID32434680show ga Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we review the current understanding of AID function. We discuss AID biochemistry and how error-free forms of DNA repair are co-opted to prioritize mutagenesis over accuracy during antibody diversification. We discuss the regulation of DNA double-strand break (DSB) repair pathways during CSR. We describe genomic targeting of AID as a multilayered process involving chromatin architecture, cis- and trans-acting factors, and determining mutagenesis - distinct from AID occupancy at loci that are spared from mutation. |*Antibody Diversity/genetics[MESH] |*Cytidine Deaminase/metabolism[MESH] |Genes, Immunoglobulin[MESH] |Humans[MESH] |Immunoglobulin Class Switching/genetics[MESH]AID in Antibody Diversification: There and Back Again (epmc).pdf DeepDyve Pubget Overpricing