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10.1186/s12967-020-02374-0 http://scihub22266oqcxt.onion/10.1186/s12967-020-02374-0 32434518!7237880!32434518     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Transl+Med 2020 ; 18 (1): 206 Nephropedia Template TP {{tp|p=32434518|t=2020. Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage |pdf=|usr=}}{{32434518}} gab.com Text Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32434518 #FOAvip BACKGROUND: Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive factor for critical illness caused by COVID-19. METHODS: The study prospectively involved 61 patients with COVID-19 infection as a derivation cohort, and 54 patients as a validation cohort. The predictive factor for critical illness was selected using LASSO regression analysis. A nomogram based on non-specific laboratory indicators was built to predict the probability of critical illness. RESULTS: The neutrophil-to-lymphocyte ratio (NLR) was identified as an independent risk factor for critical illness in patients with COVID-19 infection. The NLR had an area under receiver operating characteristic of 0.849 (95% confidence interval [CI], 0.707 to 0.991) in the derivation cohort and 0.867 (95% CI 0.747 to 0.944) in the validation cohort, the calibration curves fitted well, and the decision and clinical impact curves showed that the NLR had high standardized net benefit. In addition, the incidence of critical illness was 9.1% (1/11) for patients aged >/= 50 and having an NLR < 3.13, and 50% (7/14) patients with age >/= 50 and NLR >/= 3.13 were predicted to develop critical illness. Based on the risk stratification of NLR according to age, this study has developed a COVID-19 pneumonia management process. CONCLUSIONS: We found that NLR is a predictive factor for early-stage prediction of patients infected with COVID-19 who are likely to develop critical illness. Patients aged >/= 50 and having an NLR >/= 3.13 are predicted to develop critical illness, and they should thus have rapid access to an intensive care unit if necessary. Twit Text FOAVip Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32434518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32434518 #FOAvip English Wikipedia <ref>{{Cite pmid|32434518}}</ref> Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage #MMPMID32434518 Liu J; Liu Y; Xiang P; Pu L; Xiong H; Li C; Zhang M; Tan J; Xu Y; Song R; Song M; Wang L; Zhang W; Han B; Yang L; Wang X; Zhou G; Zhang T; Li B; Wang Y; Chen Z; Wang X J Transl Med 2020[May]; 18 (1): 206 PMID32434518show ga BACKGROUND: Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive factor for critical illness caused by COVID-19. METHODS: The study prospectively involved 61 patients with COVID-19 infection as a derivation cohort, and 54 patients as a validation cohort. The predictive factor for critical illness was selected using LASSO regression analysis. A nomogram based on non-specific laboratory indicators was built to predict the probability of critical illness. RESULTS: The neutrophil-to-lymphocyte ratio (NLR) was identified as an independent risk factor for critical illness in patients with COVID-19 infection. The NLR had an area under receiver operating characteristic of 0.849 (95% confidence interval [CI], 0.707 to 0.991) in the derivation cohort and 0.867 (95% CI 0.747 to 0.944) in the validation cohort, the calibration curves fitted well, and the decision and clinical impact curves showed that the NLR had high standardized net benefit. In addition, the incidence of critical illness was 9.1% (1/11) for patients aged >/= 50 and having an NLR < 3.13, and 50% (7/14) patients with age >/= 50 and NLR >/= 3.13 were predicted to develop critical illness. Based on the risk stratification of NLR according to age, this study has developed a COVID-19 pneumonia management process. CONCLUSIONS: We found that NLR is a predictive factor for early-stage prediction of patients infected with COVID-19 who are likely to develop critical illness. Patients aged >/= 50 and having an NLR >/= 3.13 are predicted to develop critical illness, and they should thus have rapid access to an intensive care unit if necessary. |*Critical Illness[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus/pathogenicity[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Cohort Studies[MESH] |Coronavirus Infections/blood/*diagnosis/pathology[MESH] |Disease Progression[MESH] |Female[MESH] |History, 21st Century[MESH] |Humans[MESH] |Infant[MESH] |Leukocyte Count[MESH] |Lymphocytes/*pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/*pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*diagnosis/pathology[MESH] |Prognosis[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Neutrophil-to-lymphocyte ratio predicts critical illness patients with(epmc).pdf DeepDyve Pubget Overpricing