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  • Extended ORF8 Gene Region Is Valuable in the Epidemiological Investigation of Severe Acute Respiratory Syndrome-Similar Coronavirus #MMPMID32433742
  • Chen S; Zheng X; Zhu J; Ding R; Jin Y; Zhang W; Yang H; Zheng Y; Li X; Duan G
  • J Infect Dis 2020[Jun]; 222 (2): 223-233 PMID32433742show ga
  • Severe acute respiratory syndrome coronavirus (SARS-CoV) was discovered as a novel pathogen in the 2002-2003 SARS epidemic. The emergence and disappearance of this pathogen have brought questions regarding its source and evolution. Within the genome sequences of 281 SARS-CoVs, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-related CoVs (SARSr-CoVs), a ~430 bp genomic region (from 27 701 bp to 28 131 bp in AY390556.1) with regular variations was investigated. This ~430 bp region overlaps with the ORF8 gene and is prone to deletions and nucleotide substitutions. Its complexity suggested the need for a new genotyping method for coronaviruses related to SARS-similar coronaviruses (SARS-CoV, SARSr-CoV, and SARS-CoV-2). Bat SARSr-CoV presented 3 genotypes, of which type 0 is only seen in bat SARSr-CoV, type I is present in SARS in the early phase, and type II is found in all SARS-CoV-2. This genotyping also shows potential usage in distinguishing the SARS-similar coronaviruses from different hosts and geographic areas. This genomic region has important implications for predicting the epidemic trend and studying the evolution of coronavirus.
  • |*Genome, Viral[MESH]
  • |Animals[MESH]
  • |Base Sequence[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |Chiroptera/virology[MESH]
  • |Eutheria/virology[MESH]
  • |Evolution, Molecular[MESH]
  • |Genes, Viral[MESH]
  • |Genetic Variation[MESH]
  • |Humans[MESH]
  • |Open Reading Frames[MESH]
  • |Phylogeny[MESH]
  • |SARS Virus/*genetics[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Alignment[MESH]
  • |Sequence Deletion[MESH]
  • |Spike Glycoprotein, Coronavirus/genetics[MESH]
  • |Viral Matrix Proteins/*genetics[MESH]
  • |Viverridae/virology[MESH]

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  • suck abstract from ncbi

    223 2.222 2020