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10.1038/s41467-020-16505-0 http://scihub22266oqcxt.onion/10.1038/s41467-020-16505-0 32433465!7239918!32433465     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 2601 Nephropedia Template TP {{tp|p=32433465|t=2020. Immunogenicity of a DNA vaccine candidate for COVID-19 |pdf=|usr=}}{{32433465}} gab.com Text Immunogenicity of a DNA vaccine candidate for COVID-19 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32433465 #FOAvip The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to control further dissemination of the disease. We have previously engineered a synthetic DNA vaccine targeting the MERS coronavirus Spike (S) protein, the major surface antigen of coronaviruses, which is currently in clinical study. Here we build on this prior experience to generate a synthetic DNA-based vaccine candidate targeting SARS-CoV-2 S protein. The engineered construct, INO-4800, results in robust expression of the S protein in vitro. Following immunization of mice and guinea pigs with INO-4800 we measure antigen-specific T cell responses, functional antibodies which neutralize the SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and biodistribution of SARS-CoV-2 targeting antibodies to the lungs. This preliminary dataset identifies INO-4800 as a potential COVID-19 vaccine candidate, supporting further translational study. Twit Text FOAVip Immunogenicity of a DNA vaccine candidate for COVID-19 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32433465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32433465 #FOAvip English Wikipedia <ref>{{Cite pmid|32433465}}</ref> Immunogenicity of a DNA vaccine candidate for COVID-19 #MMPMID32433465 Smith TRF; Patel A; Ramos S; Elwood D; Zhu X; Yan J; Gary EN; Walker SN; Schultheis K; Purwar M; Xu Z; Walters J; Bhojnagarwala P; Yang M; Chokkalingam N; Pezzoli P; Parzych E; Reuschel EL; Doan A; Tursi N; Vasquez M; Choi J; Tello-Ruiz E; Maricic I; Bah MA; Wu Y; Amante D; Park DH; Dia Y; Ali AR; Zaidi FI; Generotti A; Kim KY; Herring TA; Reeder S; Andrade VM; Buttigieg K; Zhao G; Wu JM; Li D; Bao L; Liu J; Deng W; Qin C; Brown AS; Khoshnejad M; Wang N; Chu J; Wrapp D; McLellan JS; Muthumani K; Wang B; Carroll MW; Kim JJ; Boyer J; Kulp DW; Humeau LMPF; Weiner DB; Broderick KE Nat Commun 2020[May]; 11 (1): 2601 PMID32433465show ga The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to control further dissemination of the disease. We have previously engineered a synthetic DNA vaccine targeting the MERS coronavirus Spike (S) protein, the major surface antigen of coronaviruses, which is currently in clinical study. Here we build on this prior experience to generate a synthetic DNA-based vaccine candidate targeting SARS-CoV-2 S protein. The engineered construct, INO-4800, results in robust expression of the S protein in vitro. Following immunization of mice and guinea pigs with INO-4800 we measure antigen-specific T cell responses, functional antibodies which neutralize the SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and biodistribution of SARS-CoV-2 targeting antibodies to the lungs. This preliminary dataset identifies INO-4800 as a potential COVID-19 vaccine candidate, supporting further translational study. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antigens, Viral/chemistry/*immunology[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/immunology/prevention & control[MESH] |Epitope Mapping[MESH] |Guinea Pigs[MESH] |Immunity, Humoral[MESH] |Immunoglobulin G/immunology[MESH] |Lung/immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Middle East Respiratory Syndrome Coronavirus[MESH] |Models, Animal[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*immunology[MESH] |Vaccines, DNA/*immunology[MESH]Immunogenicity of a DNA vaccine candidate for COVID-19 (epmc).pdf DeepDyve Pubget Overpricing