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10.1080/22221751.2020.1772676 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1772676 32432977!7448857!32432977     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32432977&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2020 ; 9 (1): 1170-1173 Nephropedia Template TP {{tp|p=32432977|t=2020. Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture |pdf=|usr=}}{{32432977}} gab.com Text Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32432977 #FOAvip The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined the antiviral abilities of three broad-spectrum antiviral compounds gemcitabine, lycorine and oxysophoridine against SARS-CoV-2 in cell culture. We found that all three tested compounds inhibited viral replication in Vero-E6 cells at noncytotoxic concentrations. The antiviral effect of gemcitabine was suppressed efficiently by the cytidine nucleosides. Additionally, combination of gemcitabine with oxysophoridine had an additive antiviral effect against SARS-CoV-2. Our results demonstrate that broad-spectrum antiviral compounds may have a priority for the screening of antiviral compounds against newly emerging viruses to control viral infection. Twit Text FOAVip Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32432977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32432977 #FOAvip English Wikipedia <ref>{{Cite pmid|32432977}}</ref> Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture #MMPMID32432977 Zhang YN; Zhang QY; Li XD; Xiong J; Xiao SQ; Wang Z; Zhang ZR; Deng CL; Yang XL; Wei HP; Yuan ZM; Ye HQ; Zhang B Emerg Microbes Infect 2020[Dec]; 9 (1): 1170-1173 PMID32432977show ga The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined the antiviral abilities of three broad-spectrum antiviral compounds gemcitabine, lycorine and oxysophoridine against SARS-CoV-2 in cell culture. We found that all three tested compounds inhibited viral replication in Vero-E6 cells at noncytotoxic concentrations. The antiviral effect of gemcitabine was suppressed efficiently by the cytidine nucleosides. Additionally, combination of gemcitabine with oxysophoridine had an additive antiviral effect against SARS-CoV-2. Our results demonstrate that broad-spectrum antiviral compounds may have a priority for the screening of antiviral compounds against newly emerging viruses to control viral infection. |Alkaloids/*pharmacology[MESH] |Amaryllidaceae Alkaloids/*pharmacology[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects/growth & development/metabolism[MESH] |Cell Survival/drug effects[MESH] |Chlorocebus aethiops[MESH] |Chloroquine/pharmacology[MESH] |Deoxycytidine/*analogs & derivatives/pharmacology[MESH] |Dose-Response Relationship, Drug[MESH] |Drug Combinations[MESH] |Drug Synergism[MESH] |Gemcitabine[MESH] |Phenanthridines/*pharmacology[MESH] |SARS-CoV-2[MESH] |Vero Cells[MESH]Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SA(epmc).pdf DeepDyve Pubget Overpricing