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10.1515/cclm-2020-0573

http://scihub22266oqcxt.onion/10.1515/cclm-2020-0573
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32432563!ä!32432563

suck abstract from ncbi


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pmid32432563      Clin+Chem+Lab+Med 2020 ; 58 (8): 1191-1199
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  • Reporting of D-dimer data in COVID-19: some confusion and potential for misinformation #MMPMID32432563
  • Favaloro EJ; Thachil J
  • Clin Chem Lab Med 2020[Jul]; 58 (8): 1191-1199 PMID32432563show ga
  • Coronavirus disease 2019 (COVID-19) represents a new pandemic caused by severe acute respiratory syndrome virus coronavirus 2 (SARS-CoV-2). A previous pooled analysis clearly identified elevated D-dimer levels as being associated with severity of COVID-19. Since then, several other studies have provided clearer support for this initial evidence. However, potentially under-recognized by those reporting on D-dimer is the considerable variation in reporting units for D-dimer, and thus also the potential for misreporting of D-dimer data based on poor or incomplete reporting. A PubMed search was used to identify recent papers reporting on D-dimers in COVID-19-based studies. We report that: (1) most publications did not identify either the manufacturer or D-dimer product used; (2) most did not identify whether D-dimer values were reported as D-dimer units (DDU) or fibrinogen equivalent units (FEU) (~2 x differences); (3) nearly half did not identify normal cut-off values; (4) some did not report numerical findings or units for D-dimer; (5) where reported, most identified units as either mg/L or mug/mL; (6) we identified at least four errors in reporting from 21 papers. It may not be possible to truly standardize D-dimer assays, but it should be feasible to harmonize D-dimer assays to a single unit of measurement.
  • |Betacoronavirus[MESH]
  • |Blood Chemical Analysis/methods/*statistics & numerical data[MESH]
  • |COVID-19[MESH]
  • |Communication[MESH]
  • |Confusion[MESH]
  • |Coronavirus Infections/*blood[MESH]
  • |Fibrin Fibrinogen Degradation Products/*analysis[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood[MESH]


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