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10.1016/j.jacl.2020.04.008 http://scihub22266oqcxt.onion/10.1016/j.jacl.2020.04.008 32430154!7192140!32430154     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Lipidol 2020 ; 14 (3): 297-304 Nephropedia Template TP {{tp|p=32430154|t=2020. Hypolipidemia is associated with the severity of COVID-19 |pdf=|usr=}}{{32430154}} gab.com Text Hypolipidemia is associated with the severity of COVID-19 JO: J Clin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=32430154 #FOAvip BACKGROUND: Many patients with coronavirus disease 2019 (COVID-19) suffer multiple organ dysfunctions. However, whether patients develop dyslipidemia is unknown. OBJECTIVE: In this study, we aimed to investigate the pathological alterations of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and total cholesterol (TC) in COVID-19 patients and their relationships with the disease severity. METHODS: A retrospective study was performed to examine serum levels of LDL-c, HDL-c, and TC on 597 COVID-19 patients (mild: 394; severe, 171; critical: 32) who were hospitalized in our center between February 1 and March 3, 2020. Age- and gender-matched normal subjects (n = 50) who had routine laboratory lipid tests between October 1 and November 1, 2019 in our center were included as the control group. RESULTS: LDL-c and TC levels were significantly lower in COVID-19 patients as compared with normal subjects (P < .001). There were significant and gradual decreases in levels of LDL-c (median (IQR) in mg/dL, mild: 91 (76, 104); severe: 86 (69, 102); critical: 69 (48, 81); P < .02) and TC (mild: 173 (148, 203); severe: 167 (138, 197); critical: 125 (95, 162); P < .05) across all three groups. HDL-c levels only decreased significantly in critical cases as compared with levels in mild and severe cases. LDL-c and TC levels inversely correlated with C-reactive protein and interleukin-6, and positively correlated with the number of lymphocytes in patients. CONCLUSIONS: Development of hypolipidemia begins in patients with mild symptoms. It progressively becomes worse in an association with the disease severity. Twit Text FOAVip Hypolipidemia is associated with the severity of COVID-19 ????J Clin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=32430154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32430154 #FOAvip English Wikipedia <ref>{{Cite pmid|32430154}}</ref> Hypolipidemia is associated with the severity of COVID-19 #MMPMID32430154 Wei X; Zeng W; Su J; Wan H; Yu X; Cao X; Tan W; Wang H J Clin Lipidol 2020[May]; 14 (3): 297-304 PMID32430154show ga BACKGROUND: Many patients with coronavirus disease 2019 (COVID-19) suffer multiple organ dysfunctions. However, whether patients develop dyslipidemia is unknown. OBJECTIVE: In this study, we aimed to investigate the pathological alterations of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and total cholesterol (TC) in COVID-19 patients and their relationships with the disease severity. METHODS: A retrospective study was performed to examine serum levels of LDL-c, HDL-c, and TC on 597 COVID-19 patients (mild: 394; severe, 171; critical: 32) who were hospitalized in our center between February 1 and March 3, 2020. Age- and gender-matched normal subjects (n = 50) who had routine laboratory lipid tests between October 1 and November 1, 2019 in our center were included as the control group. RESULTS: LDL-c and TC levels were significantly lower in COVID-19 patients as compared with normal subjects (P < .001). There were significant and gradual decreases in levels of LDL-c (median (IQR) in mg/dL, mild: 91 (76, 104); severe: 86 (69, 102); critical: 69 (48, 81); P < .02) and TC (mild: 173 (148, 203); severe: 167 (138, 197); critical: 125 (95, 162); P < .05) across all three groups. HDL-c levels only decreased significantly in critical cases as compared with levels in mild and severe cases. LDL-c and TC levels inversely correlated with C-reactive protein and interleukin-6, and positively correlated with the number of lymphocytes in patients. CONCLUSIONS: Development of hypolipidemia begins in patients with mild symptoms. It progressively becomes worse in an association with the disease severity. |*Betacoronavirus[MESH] |*Severity of Illness Index[MESH] |Aged[MESH] |COVID-19[MESH] |Cholesterol, HDL/*blood[MESH] |Cholesterol, LDL/*blood[MESH] |Cholesterol/blood[MESH] |Coronavirus Infections/*blood/diagnosis[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*blood/diagnosis[MESH] |Retrospective Studies[MESH]Hypolipidemia is associated with the severity of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing