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10.15252/emmm.202012421

http://scihub22266oqcxt.onion/10.15252/emmm.202012421
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32428990!7280589!32428990
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suck abstract from ncbi


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pmid32428990      EMBO+Mol+Med 2020 ; 12 (7): e12421
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  • The role of interleukin-6 in monitoring severe case of coronavirus disease 2019 #MMPMID32428990
  • Liu T; Zhang J; Yang Y; Ma H; Li Z; Zhang J; Cheng J; Zhang X; Zhao Y; Xia Z; Zhang L; Wu G; Yi J
  • EMBO Mol Med 2020[Jul]; 12 (7): e12421 PMID32428990show ga
  • Progression to severe disease is a difficult problem in treating coronavirus disease 2019 (COVID-19). The purpose of this study is to explore changes in markers of severe disease in COVID-19 patients. Sixty-nine severe COVID-19 patients were included. Patients with severe disease showed significant lymphocytopenia. Elevated level of lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, and D-dimer was found in most severe cases. Baseline interleukin-6 (IL-6) was found to be associated with COVID-19 severity. Indeed, the significant increase of baseline IL-6 was positively correlated with the maximal body temperature during hospitalization and with the increased baseline of CRP, LDH, ferritin, and D-dimer. High baseline IL-6 was also associated with more progressed chest computed tomography (CT) findings. Significant decrease in IL-6 and improved CT assessment was found in patients during recovery, while IL-6 was further increased in exacerbated patients. Collectively, our results suggest that the dynamic change in IL-6 can be used as a marker for disease monitoring in patients with severe COVID-19.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |Biomarkers/analysis[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/drug therapy/*pathology/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*analysis[MESH]
  • |Lymphopenia/etiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/*pathology/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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