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10.1055/s-0040-1712103 http://scihub22266oqcxt.onion/10.1055/s-0040-1712103 32428965!7356075!32428965     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32428965&cmd=llinks): Failed to open stream: HTTP request failed! 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Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries |pdf=|usr=}}{{32428965}} gab.com Text Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries JO: Am J Perinatol http://www.kidney.de/pget.php?&tw=1&pmid=32428965 #FOAvip OBJECTIVE: Pregnant women have been historically excluded from clinical trials for nonobstetric conditions, even during prior epidemics. The objective of this review is to describe the current state of research for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. STUDY DESIGN: We conducted a search of international trial registries for trials relating to the novel coronavirus. The eligibility criteria for each trial were reviewed for inclusion/exclusion of pregnant women. Relevant data were extracted and descriptive statistics were calculated for individual and combined data. The total number of trials from each registry were compared, as well as the proportions of pregnancy-related trials within each. RESULTS: Among 621,370 trials in the World Health Organization International Clinical Trials Registry, 927 (0.15%) were COVID-19 related. Of those, the majority (52%) explicitly excluded pregnancy or failed to address pregnancy at all (46%) and only 16 (1.7%) were pregnancy specific. When categorized by region, 688 (74.2%) of COVID-19 trials were in Asia, followed by 128 (13.8%) in Europe, and 66 (7.2%) in North America. Of the COVID-19 trials which included pregnant women, only three were randomized-controlled drug trials. CONCLUSION: Approximately 1.7% of current COVID-19 research is pregnancy related and the majority of trials either explicitly exclude or fail to address pregnancy. Only three interventional trials worldwide involved pregnant women. The knowledge gap concerning the safety and efficacy of interventions for COVID-19 created by the exclusion of pregnant women may ultimately harm them. While "ethical" concerns about fetal exposure are often cited, it is in fact unethical to habitually exclude pregnant women from research. KEY POINTS: . Pregnancy was excluded from past pandemic research.. . Pregnancy is being excluded from COVID-19 research.. . Exclusion of pregnant women is potentially harmful.. Twit Text FOAVip Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries ????Am J Perinatol http://www.kidney.de/pget.php?&tw=1&pmid=32428965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32428965 #FOAvip English Wikipedia <ref>{{Cite pmid|32428965}}</ref> Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries #MMPMID32428965 Smith DD; Pippen JL; Adesomo AA; Rood KM; Landon MB; Costantine MM Am J Perinatol 2020[Jun]; 37 (8): 792-799 PMID32428965show ga OBJECTIVE: Pregnant women have been historically excluded from clinical trials for nonobstetric conditions, even during prior epidemics. The objective of this review is to describe the current state of research for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. STUDY DESIGN: We conducted a search of international trial registries for trials relating to the novel coronavirus. The eligibility criteria for each trial were reviewed for inclusion/exclusion of pregnant women. Relevant data were extracted and descriptive statistics were calculated for individual and combined data. The total number of trials from each registry were compared, as well as the proportions of pregnancy-related trials within each. RESULTS: Among 621,370 trials in the World Health Organization International Clinical Trials Registry, 927 (0.15%) were COVID-19 related. Of those, the majority (52%) explicitly excluded pregnancy or failed to address pregnancy at all (46%) and only 16 (1.7%) were pregnancy specific. When categorized by region, 688 (74.2%) of COVID-19 trials were in Asia, followed by 128 (13.8%) in Europe, and 66 (7.2%) in North America. Of the COVID-19 trials which included pregnant women, only three were randomized-controlled drug trials. CONCLUSION: Approximately 1.7% of current COVID-19 research is pregnancy related and the majority of trials either explicitly exclude or fail to address pregnancy. Only three interventional trials worldwide involved pregnant women. The knowledge gap concerning the safety and efficacy of interventions for COVID-19 created by the exclusion of pregnant women may ultimately harm them. While "ethical" concerns about fetal exposure are often cited, it is in fact unethical to habitually exclude pregnant women from research. KEY POINTS: . Pregnancy was excluded from past pandemic research.. . Pregnancy is being excluded from COVID-19 research.. . Exclusion of pregnant women is potentially harmful.. |*Clinical Trials as Topic/ethics/organization & administration/standards[MESH] |*Coronavirus Infections/epidemiology/therapy[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/epidemiology/therapy[MESH] |*Pregnancy Complications, Infectious/epidemiology/therapy[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |Eligibility Determination/*standards[MESH] |Female[MESH] |Global Health[MESH] |Humans[MESH] |Patient Selection/*ethics[MESH] |Pregnancy[MESH] |Registries/*statistics & numerical data[MESH]Exclusion of Pregnant Women from Clinical Trials during the Coronaviru(epmc).pdf DeepDyve Pubget Overpricing