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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Obesity+(Silver+Spring) 2020 ; 28 (9): 1586-1589 Nephropedia Template TP
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Increased ACE2 Expression in Bronchial Epithelium of COPD Patients who are Overweight #MMPMID32428380
Higham A; Singh D
Obesity (Silver Spring) 2020[Sep]; 28 (9): 1586-1589 PMID32428380show ga
OBJECTIVE: Mortality from coronavirus disease 2019 (COVID-19) is increased in patients with chronic obstructive pulmonary disease (COPD). Furthermore, higher BMI is related to severe disease. Severe acute respiratory syndrome coronavirus 2 utilizes angiotensin converting enzyme 2 (ACE2) to gain cellular entry. METHODS: Whether ACE2 bronchial epithelial expression is increased in COPD patients who have overweight compared with those who do not was investigated by RNA sequencing. RESULTS: Increased ACE2 expression was observed in patients with COPD with overweight (mean BMI, 29 kg/m(2) ) compared with those without overweight (mean BMI, 21 kg/m(2) ) (P = 0.004). CONCLUSIONS: Increased ACE2 expression may cause increased severe acute respiratory syndrome coronavirus 2 infection of the respiratory tract. Overweight COPD patients may be at greater risk for developing severe COVID-19.