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10.1002/oby.22907

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32428380!7276828!32428380
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suck abstract from ncbi


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pmid32428380      Obesity+(Silver+Spring) 2020 ; 28 (9): 1586-1589
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  • Increased ACE2 Expression in Bronchial Epithelium of COPD Patients who are Overweight #MMPMID32428380
  • Higham A; Singh D
  • Obesity (Silver Spring) 2020[Sep]; 28 (9): 1586-1589 PMID32428380show ga
  • OBJECTIVE: Mortality from coronavirus disease 2019 (COVID-19) is increased in patients with chronic obstructive pulmonary disease (COPD). Furthermore, higher BMI is related to severe disease. Severe acute respiratory syndrome coronavirus 2 utilizes angiotensin converting enzyme 2 (ACE2) to gain cellular entry. METHODS: Whether ACE2 bronchial epithelial expression is increased in COPD patients who have overweight compared with those who do not was investigated by RNA sequencing. RESULTS: Increased ACE2 expression was observed in patients with COPD with overweight (mean BMI, 29 kg/m(2) ) compared with those without overweight (mean BMI, 21 kg/m(2) ) (P = 0.004). CONCLUSIONS: Increased ACE2 expression may cause increased severe acute respiratory syndrome coronavirus 2 infection of the respiratory tract. Overweight COPD patients may be at greater risk for developing severe COVID-19.
  • |*Bronchi[MESH]
  • |Aged[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections[MESH]
  • |Epithelium/*metabolism[MESH]
  • |Female[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Overweight/*complications[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/*genetics[MESH]
  • |Pneumonia, Viral[MESH]
  • |Pulmonary Disease, Chronic Obstructive/complications/*genetics[MESH]


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