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10.1097/TA.0000000000002786 http://scihub22266oqcxt.onion/10.1097/TA.0000000000002786 32427773!7484332!32427773     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32427773&cmd=llinks): Failed to open stream: HTTP request failed! 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Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series |pdf=|usr=}}{{32427773}} gab.com Text Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series JO: J Trauma Acute Care Surg http://www.kidney.de/pget.php?&tw=1&pmid=32427773 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic coagulopathy is common in critically ill patients suffering from COVID-19, with associated high rates of respiratory failure requiring prolonged periods of mechanical ventilation. Here, we report a case series of five patients suffering from profound, medically refractory COVID-19-associated respiratory failure who were treated with fibrinolytic therapy using tissue plasminogen activator (tPA; alteplase). All five patients appeared to have an improved respiratory status following tPA administration: one patient had an initial marked improvement that partially regressed after several hours, one patient had transient improvements that were not sustained, and three patients had sustained clinical improvements following tPA administration. LEVEL OF EVIDENCE: Therapeutic, Level V. Twit Text FOAVip Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series ????J Trauma Acute Care Surg http://www.kidney.de/pget.php?&tw=1&pmid=32427773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32427773 #FOAvip English Wikipedia <ref>{{Cite pmid|32427773}}</ref> Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series #MMPMID32427773 Barrett CD; Oren-Grinberg A; Chao E; Moraco AH; Martin MJ; Reddy SH; Ilg AM; Jhunjhunwala R; Uribe M; Moore HB; Moore EE; Baedorf-Kassis EN; Krajewski ML; Talmor DS; Shaefi S; Yaffe MB J Trauma Acute Care Surg 2020[Sep]; 89 (3): 453-457 PMID32427773show ga The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic coagulopathy is common in critically ill patients suffering from COVID-19, with associated high rates of respiratory failure requiring prolonged periods of mechanical ventilation. Here, we report a case series of five patients suffering from profound, medically refractory COVID-19-associated respiratory failure who were treated with fibrinolytic therapy using tissue plasminogen activator (tPA; alteplase). All five patients appeared to have an improved respiratory status following tPA administration: one patient had an initial marked improvement that partially regressed after several hours, one patient had transient improvements that were not sustained, and three patients had sustained clinical improvements following tPA administration. LEVEL OF EVIDENCE: Therapeutic, Level V. |*Betacoronavirus[MESH] |Adult[MESH] |Aged[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/epidemiology/therapy[MESH] |Critical Illness/*therapy[MESH] |Female[MESH] |Fibrinolytic Agents/therapeutic use[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/epidemiology/therapy[MESH] |Respiration, Artificial/*methods[MESH] |Respiratory Insufficiency/etiology/*therapy[MESH] |SARS-CoV-2[MESH] |Thrombolytic Therapy/*methods[MESH]Rescue therapy for severe COVID-19-associated acute respiratory distre(epmc).pdf DeepDyve Pubget Overpricing