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10.3389/fimmu.2020.00827

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.00827
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32425950!7205903!32425950
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suck abstract from ncbi


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pmid32425950      Front+Immunol 2020 ; 11 (ä): 827
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  • Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) #MMPMID32425950
  • Diao B; Wang C; Tan Y; Chen X; Liu Y; Ning L; Chen L; Li M; Liu Y; Wang G; Yuan Z; Feng Z; Zhang Y; Wu Y; Chen Y
  • Front Immunol 2020[]; 11 (ä): 827 PMID32425950show ga
  • Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. Methods: We retrospectively reviewed the counts of T cells and serum cytokine concentration from data of 522 patients with laboratory-confirmed COVID-19 and 40 healthy controls. In addition, the expression of T cell exhaustion markers were measured in 14 COVID-19 cases. Results: The number of total T cells, CD4(+) and CD8(+) T cells were dramatically reduced in COVID-19 patients, especially in patients requiring Intensive Care Unit (ICU) care. Counts of total T cells, CD8(+) T cells or CD4(+) T cells lower than 800, 300, or 400/muL, respectively, were negatively correlated with patient survival. T cell numbers were negatively correlated to serum IL-6, IL-10, and TNF-alpha concentration, with patients in the disease resolution period showing reduced IL-6, IL-10, and TNF-alpha concentrations and restored T cell counts. T cells from COVID-19 patients had significantly higher levels of the exhausted marker PD-1. Increasing PD-1 and Tim-3 expression on T cells was seen as patients progressed from prodromal to overtly symptomatic stages. Conclusions: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. Non-ICU patients with total T cells counts lower than 800/muL may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition.
  • |Betacoronavirus/*physiology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/blood/*immunology/pathology[MESH]
  • |Cytokines/blood[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*immunology/pathology[MESH]
  • |SARS-CoV-2[MESH]


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