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10.1016/j.jaci.2020.05.008 http://scihub22266oqcxt.onion/10.1016/j.jaci.2020.05.008 32425269!7233239!32425269     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2020 ; 146 (1): 128-136.e4 Nephropedia Template TP {{tp|p=32425269|t=2020. Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 |pdf=|usr=}}{{32425269}} gab.com Text Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32425269 #FOAvip BACKGROUND: Coronavirus disease 2019 (COVID-19) can manifest as a viral-induced hyperinflammation with multiorgan involvement. Such patients often experience rapid deterioration and need for mechanical ventilation. Currently, no prospectively validated biomarker of impending respiratory failure is available. OBJECTIVE: We aimed to identify and prospectively validate biomarkers that allow the identification of patients in need of impending mechanical ventilation. METHODS: Patients with COVID-19 who were hospitalized from February 29 to April 9, 2020, were analyzed for baseline clinical and laboratory findings at admission and during the disease. Data from 89 evaluable patients were available for the purpose of analysis comprising an initial evaluation cohort (n = 40) followed by a temporally separated validation cohort (n = 49). RESULTS: We identified markers of inflammation, lactate dehydrogenase, and creatinine as the variables most predictive of respiratory failure in the evaluation cohort. Maximal IL-6 level before intubation showed the strongest association with the need for mechanical ventilation, followed by maximal CRP level. The respective AUC values for IL-6 and CRP levels in the evaluation cohort were 0.97 and 0.86, and they were similar in the validation cohort (0.90 and 0.83, respectively). The calculated optimal cutoff values during the course of disease from the evaluation cohort (IL-6 level > 80 pg/mL and CRP level > 97 mg/L) both correctly classified 80% of patients in the validation cohort regarding their risk of respiratory failure. CONCLUSION: The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. Twit Text FOAVip Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32425269 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32425269 #FOAvip English Wikipedia <ref>{{Cite pmid|32425269}}</ref> Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 #MMPMID32425269 Herold T; Jurinovic V; Arnreich C; Lipworth BJ; Hellmuth JC; von Bergwelt-Baildon M; Klein M; Weinberger T J Allergy Clin Immunol 2020[Jul]; 146 (1): 128-136.e4 PMID32425269show ga BACKGROUND: Coronavirus disease 2019 (COVID-19) can manifest as a viral-induced hyperinflammation with multiorgan involvement. Such patients often experience rapid deterioration and need for mechanical ventilation. Currently, no prospectively validated biomarker of impending respiratory failure is available. OBJECTIVE: We aimed to identify and prospectively validate biomarkers that allow the identification of patients in need of impending mechanical ventilation. METHODS: Patients with COVID-19 who were hospitalized from February 29 to April 9, 2020, were analyzed for baseline clinical and laboratory findings at admission and during the disease. Data from 89 evaluable patients were available for the purpose of analysis comprising an initial evaluation cohort (n = 40) followed by a temporally separated validation cohort (n = 49). RESULTS: We identified markers of inflammation, lactate dehydrogenase, and creatinine as the variables most predictive of respiratory failure in the evaluation cohort. Maximal IL-6 level before intubation showed the strongest association with the need for mechanical ventilation, followed by maximal CRP level. The respective AUC values for IL-6 and CRP levels in the evaluation cohort were 0.97 and 0.86, and they were similar in the validation cohort (0.90 and 0.83, respectively). The calculated optimal cutoff values during the course of disease from the evaluation cohort (IL-6 level > 80 pg/mL and CRP level > 97 mg/L) both correctly classified 80% of patients in the validation cohort regarding their risk of respiratory failure. CONCLUSION: The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. |*Respiration, Artificial[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Betacoronavirus[MESH] |Biomarkers/*blood[MESH] |C-Reactive Protein/analysis/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/*blood/therapy[MESH] |Female[MESH] |Humans[MESH] |Interleukin-6/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*blood/therapy[MESH] |Respiratory Insufficiency/blood/therapy/virology[MESH] |SARS-CoV-2[MESH]Elevated levels of IL-6 and CRP predict the need for mechanical ventil(epmc).pdf DeepDyve Pubget Overpricing