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10.1111/tra.12738 http://scihub22266oqcxt.onion/10.1111/tra.12738 32424954!7276787!32424954     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Traffic 2020 ; 21 (8): 545-551 Nephropedia Template TP {{tp|p=32424954|t=2020. The hypothetical role of phosphatidic acid in subverting ER membranes during SARS-CoV infection |pdf=|usr=}}{{32424954}} gab.com Text The hypothetical role of phosphatidic acid in subverting ER membranes during SARS-CoV infection JO: Traffic http://www.kidney.de/pget.php?&tw=1&pmid=32424954 #FOAvip Positive sense (+) RNA viruses exploit membranes from a variety of cellular organelles to support the amplification of their genomes. This association concurs with the formation of vesicles whose main morphological feature is that of being wrapped by a double membrane. In the case of the SARS-CoV virus, the outer membrane is not discrete for each vesicle, but seems to be continuous and shared between many individual vesicles, a difference with other +RNA viruses whose nature has remained elusive. I present morphological, biochemical and pharmacological arguments defending the striking analogy of this arrangement and that of entangled, nascent Lipid Droplets whose birth has been aborted by an excess of Phosphatidic Acid. Since Phosphatidic Acid can be targeted with therapeutical purposes, considering this working hypothesis may prove important in tackling SARS-CoV infection. Twit Text FOAVip The hypothetical role of phosphatidic acid in subverting ER membranes during SARS-CoV infection ????Traffic http://www.kidney.de/pget.php?&tw=1&pmid=32424954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32424954 #FOAvip English Wikipedia <ref>{{Cite pmid|32424954}}</ref> The hypothetical role of phosphatidic acid in subverting ER membranes during SARS-CoV infection #MMPMID32424954 Moriel-Carretero M Traffic 2020[Aug]; 21 (8): 545-551 PMID32424954show ga Positive sense (+) RNA viruses exploit membranes from a variety of cellular organelles to support the amplification of their genomes. This association concurs with the formation of vesicles whose main morphological feature is that of being wrapped by a double membrane. In the case of the SARS-CoV virus, the outer membrane is not discrete for each vesicle, but seems to be continuous and shared between many individual vesicles, a difference with other +RNA viruses whose nature has remained elusive. I present morphological, biochemical and pharmacological arguments defending the striking analogy of this arrangement and that of entangled, nascent Lipid Droplets whose birth has been aborted by an excess of Phosphatidic Acid. Since Phosphatidic Acid can be targeted with therapeutical purposes, considering this working hypothesis may prove important in tackling SARS-CoV infection. |*Models, Biological[MESH] |Betacoronavirus/pathogenicity/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*metabolism/*virology[MESH] |Endoplasmic Reticulum/*metabolism/*virology[MESH] |Host Microbial Interactions/physiology[MESH] |Humans[MESH] |Lipid Droplets/metabolism/virology[MESH] |Pandemics[MESH] |Phosphatidic Acids/*metabolism[MESH] |Pneumonia, Viral/*metabolism/*virology[MESH] |SARS-CoV-2[MESH]The hypothetical role of phosphatidic acid in subverting ER membranes (epmc).pdf DeepDyve Pubget Overpricing