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10.1177/1078155220924084

http://scihub22266oqcxt.onion/10.1177/1078155220924084
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32423324!ä!32423324

suck abstract from ncbi


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pmid32423324      J+Oncol+Pharm+Pract 2020 ; 26 (5): 1289-1294
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  • Clinical course of COVID-19 infection in elderly patient with melanoma on nivolumab #MMPMID32423324
  • Yekeduz E; Dursun B; Aydin GC; Yazgan SC; Ozturk HH; Azap A; Utkan G; Urun Y
  • J Oncol Pharm Pract 2020[Jul]; 26 (5): 1289-1294 PMID32423324show ga
  • Outbreak of the new type coronavirus infection, known as coronavirus infection 2019 (COVID-19), has begun in December 2019, in Wuhan, China. As of today, 3 April 2020, 972,640 people affected and 50,325 people died from Severe Acute Respiratory Syndrome-Coronavirus 2. There is not any standard treatment for coronavirus infection 2019; however, there are promising data for hydroxychloroquine and some anti-retroviral drugs. Programmed death-1 (PD-1)/programmed death ligand-1 (PDL-1) pathway is an important target for the cancer immunotherapy. However, there is a robust pre-clinical and clinical data regarding inhibitor effect of this pathway on the acute or chronic viral infections. Thus, blockade of this pathway may lead to an anti-viral effect and decrease viral load. Here, we report the clinical course of coronavirus infection 2019 infection of a patient in whom older aged, having multiple co-morbidities, and taking nivolumab for metastatic malignant melanoma. In contrast to her older age, comorbidities, and cancer diagnosis, she was in a good condition, and there was also no pneumonia finding. We think that this good clinical course of coronavirus infection 2019 infection may be related to blockade of PD-1/PDL-1 pathway with nivolumab. It is impossible to say that blockade of PD-1/PDL-1pathway is a treatment option for COVID-19; however, we want to share our experience.
  • |*Betacoronavirus/drug effects/physiology[MESH]
  • |*Coronavirus Infections/diagnosis/epidemiology/physiopathology/virology[MESH]
  • |*Lung Neoplasms/drug therapy/secondary[MESH]
  • |*Melanoma/drug therapy/epidemiology/pathology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/diagnosis/epidemiology/physiopathology/virology[MESH]
  • |Aged[MESH]
  • |Antineoplastic Agents, Immunological/administration & dosage/immunology[MESH]
  • |Antiviral Agents/administration & dosage[MESH]
  • |Azithromycin/*administration & dosage[MESH]
  • |COVID-19[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/administration & dosage[MESH]
  • |Multiple Chronic Conditions/epidemiology[MESH]
  • |Nivolumab/*administration & dosage/immunology[MESH]
  • |Oseltamivir/*administration & dosage[MESH]
  • |Programmed Cell Death 1 Receptor/antagonists & inhibitors[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed/methods[MESH]


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