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10.3390/foods9050630 http://scihub22266oqcxt.onion/10.3390/foods9050630 32423148!7278878!32423148     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Foods 2020 ; 9 (5): ä Nephropedia Template TP {{tp|p=32423148|t=2020. Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its beta-Cyclodextrin (beta-CD) Inclusion Complex in Animal Inflammation Models |pdf=|usr=}}{{32423148}} gab.com Text Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its beta-Cyclodextrin (beta-CD) Inclusion Complex in Animal Inflammation Models JO: Foods http://www.kidney.de/pget.php?&tw=1&pmid=32423148 #FOAvip Isopulegol (ISO) is an alcoholic monoterpene widely found in different plant species, such as Melissa officinalis, and has already been reported to have a number of pharmacological properties. Like other terpenes, ISO is a highly volatile compound that is slightly soluble in water, so its inclusion into cyclodextrins (CDs) is an interesting approach to increase its solubility and bioavailability. Thus, our aim was to evaluate the antiedematogenic and anti-inflammatory activity of isopulegol and a beta-cyclodextrin-isopulegol inclusion complex (ISO/beta-CD) in rodent models. For the anti-inflammatory activity evaluation, antiedematogenic plethysmometry and acute (peritonitis and pleurisy), as well as chronic (cotton pellet-induced granuloma) anti-inflammatory models, were used. The docking procedure is used to evaluate, analyze, and predict their binding mode of interaction with H1 and Cox-2 receptors. The animals (n = 6) were divided into groups: ISO and ISO/beta-CD, negative control (saline), and positive control (indomethacin and promethazine). ISO and ISO/beta-CD were able to reduce acute inflammatory activity by decreasing albumin extravasation, leukocyte migration, and MPO concentration, and reducing exudate levels of IL-1beta and TNF-alpha. ISO and ISO/beta-CD significantly inhibited edematogenic activity in carrageenan- and dextran-induced paw edema. Moreover, both significantly reduced chronic inflammatory processes, given the lower weight and protein concentration of granulomas in the foreign body granulomatous inflammation model. The results suggest that the inclusion of ISO in beta-cyclodextrins improves its pharmacological properties, with the histamine and prostaglandin pathways as probable mechanisms of inhibition, and also reinforces the anti-inflammatory profile of this terpene. Twit Text FOAVip Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its beta-Cyclodextrin (beta-CD) Inclusion Complex in Animal Inflammation Models ????Foods http://www.kidney.de/pget.php?&tw=1&pmid=32423148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32423148 #FOAvip English Wikipedia <ref>{{Cite pmid|32423148}}</ref> Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its beta-Cyclodextrin (beta-CD) Inclusion Complex in Animal Inflammation Models #MMPMID32423148 Ramos AGB; de Menezes IRA; da Silva MSA; Torres Pessoa R; de Lacerda Neto LJ; Rocha Santos Passos F; Melo Coutinho HD; Iriti M; Quintans-Junior LJ Foods 2020[May]; 9 (5): ä PMID32423148show ga Isopulegol (ISO) is an alcoholic monoterpene widely found in different plant species, such as Melissa officinalis, and has already been reported to have a number of pharmacological properties. Like other terpenes, ISO is a highly volatile compound that is slightly soluble in water, so its inclusion into cyclodextrins (CDs) is an interesting approach to increase its solubility and bioavailability. Thus, our aim was to evaluate the antiedematogenic and anti-inflammatory activity of isopulegol and a beta-cyclodextrin-isopulegol inclusion complex (ISO/beta-CD) in rodent models. For the anti-inflammatory activity evaluation, antiedematogenic plethysmometry and acute (peritonitis and pleurisy), as well as chronic (cotton pellet-induced granuloma) anti-inflammatory models, were used. The docking procedure is used to evaluate, analyze, and predict their binding mode of interaction with H1 and Cox-2 receptors. The animals (n = 6) were divided into groups: ISO and ISO/beta-CD, negative control (saline), and positive control (indomethacin and promethazine). ISO and ISO/beta-CD were able to reduce acute inflammatory activity by decreasing albumin extravasation, leukocyte migration, and MPO concentration, and reducing exudate levels of IL-1beta and TNF-alpha. ISO and ISO/beta-CD significantly inhibited edematogenic activity in carrageenan- and dextran-induced paw edema. Moreover, both significantly reduced chronic inflammatory processes, given the lower weight and protein concentration of granulomas in the foreign body granulomatous inflammation model. The results suggest that the inclusion of ISO in beta-cyclodextrins improves its pharmacological properties, with the histamine and prostaglandin pathways as probable mechanisms of inhibition, and also reinforces the anti-inflammatory profile of this terpene. äAntiedematogenic and Anti-Inflammatory Activity of the Monoterpene Iso(epmc).pdf DeepDyve Pubget Overpricing