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10.1016/j.ijid.2020.05.050 http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.05.050 32422376!7228890!32422376     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2020 ; 97 (ä): 215-218 Nephropedia Template TP {{tp|p=32422376|t=2020. Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report |pdf=|usr=}}{{32422376}} gab.com Text Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32422376 #FOAvip We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection. Twit Text FOAVip Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32422376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32422376 #FOAvip English Wikipedia <ref>{{Cite pmid|32422376}}</ref> Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report #MMPMID32422376 Franzetti M; Pozzetti U; Carugati M; Pandolfo A; Molteni C; Faccioli P; Castaldo G; Longoni E; Ormas V; Iemoli E; Piconi S Int J Infect Dis 2020[Aug]; 97 (ä): 215-218 PMID32422376show ga We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection. |*Betacoronavirus/drug effects[MESH] |Adenosine Monophosphate/*analogs & derivatives/therapeutic use[MESH] |Alanine/*analogs & derivatives/therapeutic use[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy[MESH] |Drug Combinations[MESH] |Humans[MESH] |Interleukin 1 Receptor Antagonist Protein/*therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Receptors, Interleukin-1/*antagonists & inhibitors[MESH] |Respiratory Insufficiency/*drug therapy[MESH]Interleukin-1 receptor antagonist anakinra in association with remdesi(epmc).pdf DeepDyve Pubget Overpricing