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10.1016/j.etap.2020.103411 http://scihub22266oqcxt.onion/10.1016/j.etap.2020.103411 32422280!7227557!32422280     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Environ+Toxicol+Pharmacol 2020 ; 78 (ä): 103411 Nephropedia Template TP {{tp|p=32422280|t=2020. Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking |pdf=|usr=}}{{32422280}} gab.com Text Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking JO: Environ Toxicol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32422280 #FOAvip The effects of obesity and smoking in the coronavirus disease 2019 (COVID-19) pandemic remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), is the human cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. ACE2 expression increases on lung alveolar epithelial cells and adipose tissue due to obesity, smoking and air pollution. A significant relationship exists between air pollution and SARS-CoV-2 infection, as more severe COVID-19 symptoms occur in smokers; comorbid conditions due to obesity or excess ectopic fat accumulation as underlying risk factors for severe COVID-19 strongly encourage the virus/ACE2 receptor-ligand interaction concept. Indeed, obesity, air pollution and smoking associated risk factors share underlying pathophysiologies that are related to the Renin-Angiotensin-System in SARS-CoV-2 infection. The aim of this review is to emphasize the mechanism of receptor-ligand interaction and its impact on the enhanced risk of death due to SARS-CoV-2 infection. Twit Text FOAVip Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking ????Environ Toxicol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32422280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32422280 #FOAvip English Wikipedia <ref>{{Cite pmid|32422280}}</ref> Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking #MMPMID32422280 Engin AB; Engin ED; Engin A Environ Toxicol Pharmacol 2020[Aug]; 78 (ä): 103411 PMID32422280show ga The effects of obesity and smoking in the coronavirus disease 2019 (COVID-19) pandemic remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), is the human cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. ACE2 expression increases on lung alveolar epithelial cells and adipose tissue due to obesity, smoking and air pollution. A significant relationship exists between air pollution and SARS-CoV-2 infection, as more severe COVID-19 symptoms occur in smokers; comorbid conditions due to obesity or excess ectopic fat accumulation as underlying risk factors for severe COVID-19 strongly encourage the virus/ACE2 receptor-ligand interaction concept. Indeed, obesity, air pollution and smoking associated risk factors share underlying pathophysiologies that are related to the Renin-Angiotensin-System in SARS-CoV-2 infection. The aim of this review is to emphasize the mechanism of receptor-ligand interaction and its impact on the enhanced risk of death due to SARS-CoV-2 infection. |*Risk Factors[MESH] |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/*epidemiology[MESH] |Humans[MESH] |Obesity/*complications[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics[MESH] |Pneumonia, Viral/*complications/*epidemiology[MESH] |Renin-Angiotensin System[MESH]Two important controversial risk factors in SARS-CoV-2 infection: Obes(epmc).pdf DeepDyve Pubget Overpricing