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Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York #MMPMID32422233
Metabolism 2020[Jul]; 108 (?): 154262 PMID32422233show ga
BACKGROUND & AIMS: New York is the current epicenter of Coronavirus disease 2019 (COVID-19) pandemic. The underrepresented minorities, where the prevalence of obesity is higher, appear to be affected disproportionately. Our objectives were to assess the characteristics and early outcomes of patients hospitalized with COVID-19 in the Bronx and investigate whether obesity is associated with worse outcomes independently from age, gender and other comorbidities. METHODS: This retrospective study included the first 200 patients admitted to a tertiary medical center with COVID-19. The electronic medical records were reviewed at least three weeks after admission. The primary endpoint was in-hospital mortality. RESULTS: 200 patients were included (female sex: 102, African American: 102). The median BMI was 30?kg/m(2). The median age was 64?years. Hypertension (76%), hyperlipidemia (46.2%), and diabetes (39.5%) were the three most common comorbidities. Fever (86%), cough (76.5%), and dyspnea (68%) were the three most common symptoms. 24% died during hospitalization (BMI?/=?35?kg/m(2): 34.8%, p?=?0.03). Increasing age (analyzed in quartiles), male sex, BMI?>/=?35?kg/m(2) (reference: BMI 25-34?kg/m(2)), heart failure, CAD, and CKD or ESRD were found to have a significant univariate association with mortality. The multivariate analysis demonstrated that BMI?>/=?35?kg/m(2) (reference: BMI 25-34?kg/m(2), OR: 3.78; 95% CI: 1.45-9.83; p?=?0.006), male sex (OR: 2.74; 95% CI: 1.25-5.98; p?=?0.011) and increasing age (analyzed in quartiles, OR: 1.73; 95% CI: 1.13-2.63; p?=?0.011) were independently associated with higher in-hospital mortality. Similarly, age, male sex, BMI?>/=?35?kg/m(2) and current or prior smoking were significant predictors for increasing oxygenation requirements in the multivariate analysis, while male sex, age and BMI?>/=?35?kg/m(2) were significant predictors in the multivariate analysis for the outcome of intubation. CONCLUSIONS: In this cohort of hospitalized patients with COVID-19 in a minority-predominant population, severe obesity, increasing age, and male sex were independently associated with higher in-hospital mortality and in general worse in-hospital outcomes.
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Metabolism 2020 ; 108 (?): 154262
