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10.1016/j.cytox.2020.100029 http://scihub22266oqcxt.onion/10.1016/j.cytox.2020.100029 32421092!7224649!32421092     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32421092&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytokine+X 2020 ; 2 (2): 100029 Nephropedia Template TP {{tp|p=32421092|t=2020. SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the culprit lesion of ARDS onset? What is there besides Tocilizumab? SGP130Fc |pdf=|usr=}}{{32421092}} gab.com Text SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the culprit lesion of ARDS onset What is there besides Tocilizumab SGP130Fc JO: Cytokine X http://www.kidney.de/pget.php?&tw=1&pmid=32421092 #FOAvip Since the outbreak of COVID-19 many studies have been published showing possible therapies, here the author discusses the end of stage disease related drugs, like Tocilizumab which is currently being used in ARDS patients. In some patients, disease progression leads to an enormous secretion of cytokines, known as cytokine storm, among those cytokines IL-6 plays an important role. Here the author shows how IL-6 has both pro and anti-inflammatory properties, depending on the pathway of transduction: soluble (trans-signaling) or membrane-related (classic signaling), and suggests how targeting only the pro-inflammatory pathway, with SGP130Fc, could be a better option then targeting them both. Other possible IL-6 pathway inhibitors such as Ruxolitinib and Baricinitib are then analyzed, underlying how they lack the benefit of targeting only the pro-inflammatory pathway. Twit Text FOAVip SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the culprit lesion of ARDS onset What is there besides Tocilizumab SGP130Fc ????Cytokine X http://www.kidney.de/pget.php?&tw=1&pmid=32421092 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32421092 #FOAvip English Wikipedia <ref>{{Cite pmid|32421092}}</ref> SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the culprit lesion of ARDS onset? What is there besides Tocilizumab? SGP130Fc #MMPMID32421092 Magro G Cytokine X 2020[Jun]; 2 (2): 100029 PMID32421092show ga Since the outbreak of COVID-19 many studies have been published showing possible therapies, here the author discusses the end of stage disease related drugs, like Tocilizumab which is currently being used in ARDS patients. In some patients, disease progression leads to an enormous secretion of cytokines, known as cytokine storm, among those cytokines IL-6 plays an important role. Here the author shows how IL-6 has both pro and anti-inflammatory properties, depending on the pathway of transduction: soluble (trans-signaling) or membrane-related (classic signaling), and suggests how targeting only the pro-inflammatory pathway, with SGP130Fc, could be a better option then targeting them both. Other possible IL-6 pathway inhibitors such as Ruxolitinib and Baricinitib are then analyzed, underlying how they lack the benefit of targeting only the pro-inflammatory pathway. äSARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the culprit lesion (epmc).pdf DeepDyve Pubget Overpricing