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10.23750/abm.v91i2.9698

http://scihub22266oqcxt.onion/10.23750/abm.v91i2.9698
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32420934!7569632!32420934
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suck abstract from ncbi


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pmid32420934      Acta+Biomed 2020 ; 91 (2): 106-112
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  • Tobacco smoking and COVID-19 pandemic: old and new issues A summary of the evidence from the scientific literature #MMPMID32420934
  • Cattaruzza MS; Zaga V; Gallus S; D'Argenio P; Gorini G
  • Acta Biomed 2020[May]; 91 (2): 106-112 PMID32420934show ga
  • INTRODUCTION: COVID-19 pandemic burst onto the international scene as a new disease not affecting patients uniformly; hence it has risen many questions yet to be clarified. The aim of this study was to outline the main issues that led tobacco smoking being discussed as a potential risk factor associated with COVID-19. METHODS: articles from MEDLINE and pre-prints published from January to April 2020 were identified. RESULTS: data from China showed that men had more severe outcomes of COVID-19 than women. Since smoking prevalence is very high among Chinese men in comparison to women, it was hypothesized that smoking could be a risk factor for poor prognosis. This was also supported by the higher prevalence of comorbidities, many of which are tobacco-related diseases, in patients with severe COVID-19, who were also more likely to have a smoking history. A meta-analysis confirmed these results reporting an OR=2.25 (95% CI: 1.49-3.39) for developing severe Covid-19 among patients with a smoking history. Some authors, noticing that reported smoking prevalence among hospitalized patients was substantially below smoking prevalence in the corresponding populations, speculated a protective role of nicotine. However, it is likely that low prevalence among hospitalized patients are partially due to many smokers misclassified as nonsmokers. Tobacco smoking seems to cause a dose-dependent upregulation of the angiotensin-converting- enzyme-2 (ACE2), the virus cellular entry receptor, which could explain the higher risk of severe COVID-19 in smokers. CONCLUSIONS: There is need for further independent studies to clarify the role of smoking on COVID-19 incidence, progression and mortality.
  • |*Betacoronavirus[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*epidemiology/etiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology/etiology[MESH]
  • |Prevalence[MESH]
  • |Prognosis[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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