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10.1142/S0192415X20500391

http://scihub22266oqcxt.onion/10.1142/S0192415X20500391
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32420751!ä!32420751

suck abstract from ncbi


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pmid32420751      Am+J+Chin+Med 2020 ; 48 (4): 779-792
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  • Evaluation of the Adjuvant Efficacy of Natural Herbal Medicine on COVID-19: A Retrospective Matched Case-Control Study #MMPMID32420751
  • Zhang HT; Huang MX; Liu X; Zheng XC; Li XH; Chen GQ; Xia JY; Hong ZS
  • Am J Chin Med 2020[]; 48 (4): 779-792 PMID32420751show ga
  • Since the outbreak of Corona Virus Disease 2019 (COVID-19) in Hubei province, the epidemic scale has increased rapidly, and no effective antiviral drug therapy has been identified yet. This study aimed to evaluate the adjuvant efficacy of Natural Herbal Medicine (NHM) combined with Western medicine in the treatment of COVID-19. We performed a retrospective, 1:1 matched, case-control study of the first cohort of hospitalized COVID-19-confirmed cases (January 17, 2020 to January 28, 2020). A total of 22 of the 36 confirmed patients were included in this study, split into two groups of 11: the NHM group (NHM combined standard Western medicine treatment) and control group (standard Western medicine treatment alone). All patients received appropriate supportive care and regular clinical and laboratory monitoring. Main evaluation indicators included improvement of clinical symptoms such as fever, cough and diarrhea after hospitalization; pathogen nucleic acid test result of respiratory tract and fecal specimens of the patient after hospitalization, and change of chest CT examination after hospitalization. The duration of fever in the NHM group ([Formula: see text] days) was significantly shorter than that in the control group ([Formula: see text] days) ([Formula: see text]). During the whole hospitalization period, the number of cases with diarrhea in the NHM group (two cases) was less than that in the control group (eight cases) ([Formula: see text]). Compared with the control group ([Formula: see text]), the duration for improvement (DI) of chest CT in the NHM group ([Formula: see text]) was significantly shorter ([Formula: see text]). Our results suggest that NHM could improve the clinical symptoms of COVID-19 patients and may be effective in treating COVID-19; thus, a larger, prospective, randomized, controlled clinical trial should be conducted to further evaluate the adjuvant efficacy of NHM in the treatment of COVID-19.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |China[MESH]
  • |Cohort Studies[MESH]
  • |Combined Modality Therapy[MESH]
  • |Coronavirus Infections/complications/diagnostic imaging/*drug therapy[MESH]
  • |Drugs, Chinese Herbal/therapeutic use[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Medicine, Chinese Traditional[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Phytotherapy/*methods[MESH]
  • |Plant Preparations/*therapeutic use[MESH]
  • |Pneumonia, Viral/complications/diagnostic imaging/*drug therapy[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed[MESH]


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