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10.1186/s13027-020-00302-x

http://scihub22266oqcxt.onion/10.1186/s13027-020-00302-x
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32419838!7215134!32419838
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suck abstract from ncbi


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pmid32419838      Infect+Agent+Cancer 2020 ; 15 (ä): 32
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  • Knowledge-based repositioning of the anti-HCV direct antiviral agent Sofosbuvir as SARS-CoV-2 treatment #MMPMID32419838
  • Buonaguro L; Buonaguro FM
  • Infect Agent Cancer 2020[]; 15 (ä): 32 PMID32419838show ga
  • The new human coronavirus named SARS-CoV-2 is a positive-sense RNA virus for which no specific drugs are currently available. A knowledge-based analysis strongly suggests a possible repositioning of the anti-HCV direct antiviral agent (DAA) Sofosbuvir as treatment for SARS-CoV-2. Indeed, the RNA-dependent RNA-polymerases (RdRp) of the two viruses show high sequence and structural homology, supporting the likelihood of binding the Sofosbuvir molecule with similar efficiency. Such a repositioning would allow the containment of the SARS-CoV-2 pandemic and limit the progression of disease to potentially deadly COVID19.
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