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10.1016/j.vaccine.2020.04.034 http://scihub22266oqcxt.onion/10.1016/j.vaccine.2020.04.034 32418793!7186210!32418793     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vaccine 2020 ; 38 (28): 4464-4475 Nephropedia Template TP {{tp|p=32418793|t=2020. An effective CTL peptide vaccine for Ebola Zaire Based on Survivors CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design |pdf=|usr=}}{{32418793}} gab.com Text An effective CTL peptide vaccine for Ebola Zaire Based on Survivors CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design JO: Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=32418793 #FOAvip The 2013-2016 West Africa EBOV epidemic was the biggest EBOV outbreak to date. An analysis of virus-specific CD8+ T-cell immunity in 30 survivors showed that 26 of those individuals had a CD8+ response to at least one EBOV protein. The dominant response (25/26 subjects) was specific to the EBOV nucleocapsid protein (NP). It has been suggested that epitopes on the EBOV NP could form an important part of an effective T-cell vaccine for Ebola Zaire. We show that a 9-amino-acid peptide NP44-52 (YQVNNLEEI) located in a conserved region of EBOV NP provides protection against morbidity and mortality after mouse adapted EBOV challenge. A single vaccination in a C57BL/6 mouse using an adjuvanted microsphere peptide vaccine formulation containing NP44-52 is enough to confer immunity in mice. Our work suggests that a peptide vaccine based on CD8+ T-cell immunity in EBOV survivors is conceptually sound and feasible. Nucleocapsid proteins within SARS-CoV-2 contain multiple Class I epitopes with predicted HLA restrictions consistent with broad population coverage. A similar approach to a CTL vaccine design may be possible for that virus. Twit Text FOAVip An effective CTL peptide vaccine for Ebola Zaire Based on Survivors CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design ????Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=32418793 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32418793 #FOAvip English Wikipedia <ref>{{Cite pmid|32418793}}</ref> An effective CTL peptide vaccine for Ebola Zaire Based on Survivors CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design #MMPMID32418793 Herst CV; Burkholz S; Sidney J; Sette A; Harris PE; Massey S; Brasel T; Cunha-Neto E; Rosa DS; Chao WCH; Carback R; Hodge T; Wang L; Ciotlos S; Lloyd P; Rubsamen R Vaccine 2020[Jun]; 38 (28): 4464-4475 PMID32418793show ga The 2013-2016 West Africa EBOV epidemic was the biggest EBOV outbreak to date. An analysis of virus-specific CD8+ T-cell immunity in 30 survivors showed that 26 of those individuals had a CD8+ response to at least one EBOV protein. The dominant response (25/26 subjects) was specific to the EBOV nucleocapsid protein (NP). It has been suggested that epitopes on the EBOV NP could form an important part of an effective T-cell vaccine for Ebola Zaire. We show that a 9-amino-acid peptide NP44-52 (YQVNNLEEI) located in a conserved region of EBOV NP provides protection against morbidity and mortality after mouse adapted EBOV challenge. A single vaccination in a C57BL/6 mouse using an adjuvanted microsphere peptide vaccine formulation containing NP44-52 is enough to confer immunity in mice. Our work suggests that a peptide vaccine based on CD8+ T-cell immunity in EBOV survivors is conceptually sound and feasible. Nucleocapsid proteins within SARS-CoV-2 contain multiple Class I epitopes with predicted HLA restrictions consistent with broad population coverage. A similar approach to a CTL vaccine design may be possible for that virus. |*Drug Design[MESH] |*Viral Vaccines/chemistry/immunology[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/immunology/prevention & control[MESH] |Disease Models, Animal[MESH] |Ebola Vaccines/chemistry/*immunology[MESH] |Epitopes, T-Lymphocyte/chemistry/*immunology[MESH] |Hemorrhagic Fever, Ebola/immunology/prevention & control[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Nucleocapsid Proteins/chemistry/*immunology[MESH] |Pandemics/prevention & control[MESH] |Pneumonia, Viral/immunology/prevention & control[MESH] |T-Lymphocytes, Cytotoxic/*immunology[MESH]An effective CTL peptide vaccine for Ebola Zaire Based on Survivors C(epmc).pdf DeepDyve Pubget Overpricing